刺激响应型基因递送系统在癌症治疗中的应用  

Advances in Stimulus-Responsive Gene Delivery Systems in Cancer Therapy

作　　者：张丽华[1] 李江[1] 王娟 闫旭 王俊丽[1] 白云峰[1] 冯锋[1] ZHANG Lihua;LI Jiang;WANG Juan;YAN Xu;WANG Junli;BAI Yunfeng;FENG Feng(Shanxi Province Key Laboratory of Chemical and Biological Sensing,School of Chemistry and Chemical Engineering,Shanxi Datong University,Datong 037009,Shanxi,China)

机构地区：[1]山西大同大学化学与化工学院,化学生物传感山西省重点实验室,山西大同037009

出　　处：《材料导报》2025年第9期229-241,共13页Materials Reports

基　　金：国家自然科学基金(21908135);大同市应用基础项目(2023058);山西省高等学校大学生创新训练计划项目(XDC2023121)。

摘　　要：在过去的几十年里,癌症基因治疗已取得了巨大的进步,但较低的基因递送效率和生物利用度等不良事件仍是临床上的主要挑战。纳米递药系统在癌症治疗方面具有独特的优势。刺激响应型基因递送系统由于具有避免药物过早泄漏、提高血液循环稳定性、增加病灶药物浓度、提高药物生物利用度和减轻抗癌药物不良反应等特点,目前已成为肿瘤治疗领域的研究热点。本文分别从内源刺激(pH、酶、氧化还原、活性氧和其他)和外源刺激(磁场、热、光和超声)两个角度,详细介绍了近年来刺激响应型基因递送系统在肿瘤治疗领域的最新研究进展,并讨论了其面临的问题和挑战。Over the past decades,there has been tremendous progress in cancer gene therapy,but adverse events such as lower gene delivery efficiency and bioavailability remain major clinical challenges.Nano-delivery systems have unique advantages in cancer therapy.Due to avoiding premature drug leakage,improving blood circulation stability,increasing drug concentration in the lesion,improving drug bioavailability,and mitigating adverse reactions of anticancer drugs,stimulus-responsive gene delivery systems have become a research hotspot in cancer therapy.In this paper,the latest research progress of stimuli-responsive gene delivery systems in the field of tumor therapy over the last years is detailed,with emphasis on endogenous stimuli(pH,enzyme,redox,reactive oxygen species,and others)and exogenous stimuli(magnetic field,heat,light,and ultrasound),respectively.The problems and challenges faced by them are discussed.

关 键 词：刺激响应 纳米系统 基因递送 药物控释 癌症 

分 类 号：R7334[医药卫生—肿瘤]