加味黄芪桂枝五物汤联合常规化疗治疗胃癌患者的疗效及对血清ITGβ6、Notch-3水平的影响  

Clinical efficacy of Jiawei Huangqi Guizhi Wuwu decoction combined with conventional chemotherapy in patients with gastric cancer and its effect on serum ITGβ6 and Notch-3 levels

作　　者：张倩 张萍静 刘奕彤 郑明明 ZHANG Qian;ZHANG Pingjing;LIU Yitong;ZHENG Mingming(Department of Traditional Chinese Medicine,Bayingolin Mongolian Autonomous Prefecture People's Hospital,Bayingolin,Xinjiang 841000,China)

机构地区：[1]新疆维吾尔自治区巴音郭楞蒙古自治州人民医院中医科,新疆巴音郭楞841000

出　　处：《检验医学与临床》2025年第8期1034-1038,共5页Laboratory Medicine and Clinic

基　　金：新疆维吾尔自治区巴音郭楞蒙古自治州科学技术研究计划项目(2021075)。

摘　　要：目的探讨加味黄芪桂枝五物汤联合常规化疗治疗胃癌患者的疗效及对血清人整合素β6(ITGβ6)、Notch同源物3(Notch-3)水平的影响。方法选取2019年1月至2023年12月该院收治的130例进展期胃癌患者作为研究对象,根据随机数字表法将患者分为观察组、对照组,每组65例。对照组采用常规化疗治疗,观察组采用加味黄芪桂枝五物汤联合常规化疗治疗。比较2组临床疗效、中医证候积分、不良反应发生情况,以及肿瘤标志物、免疫功能、血清ITGβ6、Notch-3水平。结果观察组客观缓解率(ORR)、疾病控制率(DCR)高于对照组,差异均有统计学意义(P<0.05)。治疗后2组胃脘胀痛、食少纳呆、呃逆乏力、舌淡苔白评分,以及血清癌胚抗原(CEA)、细胞角蛋白(CK)、糖类抗原199(CA199)、ITGβ6、Notch-3水平、CD8^(+)T淋巴细胞比例低于治疗前,CD4^(+)T淋巴细胞、CD3^(+)T淋巴细胞比例及CD4^(+)T淋巴细胞/CD8^(+)T淋巴细胞比值高于治疗前,差异均有统计学意义(P<0.05)。治疗后观察组胃脘胀痛、食少纳呆、呃逆乏力、舌淡苔白评分,以及血清CEA、CK、CA199、ITGβ6、Notch-3水平、CD8^(+)T淋巴细胞比例低于对照组,CD4^(+)T淋巴细胞、CD3^(+)T淋巴细胞比例及CD4^(+)T淋巴细胞/CD8^(+)T淋巴细胞比值高于对照组,差异均有统计学意义(P<0.05)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论加味黄芪桂枝五物汤治疗胃癌患者的效果良好,可改善患者中医证候,降低肿瘤标志物水平,提升机体免疫功能,降低血清ITGβ6、Notch-3水平,治疗安全性良好。Objective To investigate the clinical efficacy of Jiawei Huangqi Guizhi Wuwu decoction combined with conventional chemotherapy in patients with gastric cancer and its effect on serum human integrinβ6(ITGβ6)and Notch homology 3(Notch-3)levels.Methods A total of 130 patients with advanced gastric cancer admitted to the hospital from January 2019 to December 2023 were selected as the research subjects.According to the random number table method,the patients were divided into the observation group and the control group,with 65 cases in each group.The control group was treated with conventional chemotherapy,and the observation group was treated with Jiawei Huangqi Guizhi Wuwu decoction combined with conventional chemotherapy.The clinical efficacy,Traditional Chinese Medicine(TCM)Syndrome scores,adverse reactions,tumor markers,immune function,serum ITGβ6 and Notch-3 levels were compared between the two groups.Results The objective response rate(ORR)and disease control rate(DCR)of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the epigastric distension and pain,appetite deprivation,hiccup and fatigue,pale tongue coating scores,as well as the levels of serum carcinoembryonic antigen(CEA),cytokeratin(CK),carbohydrate antigen 199(CA199),ITGβ6,Notch-3 and CD8^(+)T lymphocytes proportion in the two groups were lower than those before treatment.The proportions of CD4^(+)T lymphocytes,CD3^(+)T lymphocytes and CD4^(+)T lymphocytes/CD8^(+)T lymphocytes ratio in the two groups were higher than before treatment,and the differences were statistically significant(P<0.05).After treatment,the scores of epigastric distension and pain,appetite deprivation,hiccup and fatigue,pale tongue coating,and the levels of serum CEA,CK,CA199,ITGβ6,Notch-3 and the proportion of CD8^(+)T lymphocytes in the observation group were lower than those in the control group,and the proportions of CD4^(+)T lymphocytes,CD3^(+)T lymphocytes and CD4^(+)T lymphocyte

关 键 词：胃癌 加味黄芪桂枝五物汤 人整合素β6 Notch同源物3 临床疗效 免疫功能 

分 类 号：R735[医药卫生—肿瘤] R975[医药卫生—临床医学]