丁苯酞、替罗非班联合急诊取栓术治疗急性重症脑梗死的临床效果  

Clinical Effect of Butylphthalide,Tirofiban Combined with Emergency Embolectomy in the Treatment of Acute Severe Cerebral Infarction

作　　者：许业宦 XU Yehuan(Huantai county people's hospital neurology ward 2 Huantai,Shandong 256400)

机构地区：[1]桓台县人民医院神经内科二病区,山东桓台256400

出　　处：《智慧健康》2025年第3期72-74,78,共4页Smart Healthcare

摘　　要：目的探讨重症急性脑梗死(ACI)患者采用丁苯酞、替罗非班联合急诊取栓术治疗的临床效果。方法选取2019年1月—2024年6月本院收治的共计108例重症ACI患者,以治疗方式不同分成A组(40例)、B组(36例)、C组(32例)。其中,A组采用丁苯酞、替罗非班联合急诊取栓术治疗,B组采用替罗非班联合急诊取栓术治疗,C组采用急诊取栓术治疗,比较三组血管再通情况、神经功能。结果A组、B组血管再通情况优于C组(P<0.05),A组优于B组(P<0.05);三组术后10 d美国国立卫生研究院卒中量表(NIHSS)评分下降(P<0.05),随访3个月,改良Rankin量表(mRS)评分下降(P<0.05),A组、B组评分较C组更低(P<0.05),A组较B组更低(P<0.05)。结论丁苯酞、替罗非班联合急诊取栓术应用于重症ACI患者治疗中,能够提高临床效果,改善血管再通情况,改善神经功能。Objective To explore the clinical effect of butylphthalide and tirofiban combined with emergency embolectomy in patients with severe acute cerebral infarction(ACI).Methods A total of 108 patients with severe ACI admitted to our hospital from January 2019 to June 2024 were divided into group A(40 cases),group B(36 cases)and group C(32 cases)according to different treatment methods.Group A was treated with butylphthalide and tirofiban combined with emergency embolectomy,group B with tirofiban combined with emergency embolectomy,and group C with emergency embolectomy.Results The vascular recanalization of group A and group B was better than that of group C(P<0.05),and group A was better than group B(P<0.05).The scores of National Institutes of Health Stroke Scale(NIHSS)in the three groups decreased on 10th postoperative day(P<0.05),and the scores of modified Rankin Scale(mRS)decreased after 3 months of follow-up(P<0.05).The scores of group A and group B were lower than those of group C(P<0.05),and group A was lower than that of group B(P<0.05).Conclusion Butylphthalide and tirofiban combined with emergency embolectomy can improve the clinical effect,vascular recanalization and neurological function in patients with severe ACI.

关 键 词：丁苯酞 替罗非班 急诊取栓术 急性重症脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]