中药单体调控腺苷酸活化蛋白激酶信号通路防治脓毒症的研究进展  

Chinese Medicine Monomers Regulate AMP-activated Protein Kinase Pathway in the Prevention and Treatment of Sepsis:A Review

作　　者：刘柱 王佳巍 彭金婵 徐明瑶 黎丽群 谢胜[2] LIU Zhu;WANG Jiawei;PENG Jinchan;XU Mingyao;LI Liqun;XIE Sheng(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,China)

机构地区：[1]广西中医药大学研究生学院,南宁530001 [2]广西中医药大学第一附属医院,南宁530001

出　　处：《世界中医药》2025年第2期327-335,共9页World Chinese Medicine

基　　金：国家自然科学基金项目(82260900);国家中医药管理局高水平重点学科建设项目(zyyzdxk-2023167);广西科技计划项目(广西重点研发计划)(桂科AB23026098);广西中医药多学科交叉创新团队项目(GZKJ2307);广西岐黄学者培养项目(2022015003-01)。

摘　　要：脓毒症是一种由感染引起的全身炎症反应综合征,AMP活化的蛋白激酶(AMPK)信号通路通过调节炎症反应、改善线粒体功能、调节细胞自噬、抑制细胞凋亡、调节代谢等参与脓毒症的发生发展。中医药治疗脓毒症有独特优势,其中通过多途径、多效应、多靶点调控AMPK信号通路是其重要的作用机制之一。通过AMPK信号通路防治脓毒症的中药单体包括黄酮类(山柰酚、槲皮素、木犀草素、异槲皮苷、葛根素、柚皮素、高丽槐素)、酚类(姜黄素、原花青素、红景天苷、锦葵素、双去甲氧基姜黄素)、多糖类(黄芪多糖)、萜类(白桦脂酸、橙花叔醇、青蒿素、青蒿琥酯)、内酯类(白术内酯Ⅲ)、生物碱类(石蒜碱)、苷类(人参皂苷Rg3、栀子苷)、木脂素类(芝麻素、罗汉松脂素)等,这些中药单体能够通过激活或抑制AMPK信号通路,进而影响炎症反应、细胞凋亡和抗氧化应激,从而防治脓毒症。Sepsis is a systemic inflammatory response syndrome caused by infection.The AMP-activated protein kinase(AMPK)signaling pathway plays a role in the development of sepsis by regulating inflammation,improving mitochondrial function,modulating autophagy,inhibiting cell apoptosis,and regulating metabolism.Traditional Chinese medicine(TCM)has unique advantages in treating sepsis,one of which is its ability to regulate the AMPK signaling pathway through multiple pathways,effects,and targets.Chinese medicine monomers that prevent and treat sepsis via the AMPK signaling pathway include flavonoids(kaempferol,quercetin,luteolin,isoquercitrin,puerarin,naringenin,and maackiain),phenols(curcumin,proanthocyanidins,rhodioloside,malvidin,and dehydroxylcurcumin),polysaccharides(astragalus polysaccharide),terpenoids(betulinic acid,nerolidol,artemisinin,and artesunate),lactones(atractylenolideⅢ),alkaloids(lycorine),glycosides(ginsenoside Rg3 and gardenoside),and lignans(sesamin and matairesinol).These monomers can activate or inhibit the AMPK signaling pathway,thereby affecting inflammation,cell apoptosis,and oxidative stress to prevent and treat sepsis.

关 键 词：中药单体 AMP活化的蛋白激酶信号通路 脓毒症 黄酮类化合物 酚类化合物 多糖类化合物 药理活性 器官保护 

分 类 号：R254[医药卫生—中医内科学]