脂联素联合肿瘤标志物在子宫内膜癌组织中的水平及意义  

Levels and Significance of Adiponectin Combined With Tumor Markers in Endometrial Carcinoma Tissues

作　　者：于雷[1] 李波 白雪 YU Lei;LI Bo;BAI Xue(Department of Gynecology,the Fourth Hospital of Baotou,Inner Mongolia Autonomous Region,Baotou Inner Mongolia 014030,China)

机构地区：[1]内蒙古自治区包头市第四医院妇科,内蒙古包头014030

出　　处：《中国卫生标准管理》2025年第4期27-30,共4页China Health Standard Management

基　　金：包头医学院科学研究基金项目(自然科学类 青苗计划)(BYJJ-ZRQM 202020)。

摘　　要：目的 探讨子宫内膜病变诊断中脂联素联合肿瘤标志物的水平变化及意义。方法 回顾性选取2022年1月—2024年2月内蒙古自治区包头市第四医院子宫内膜检查患者130例,依据疾病类型方法分为子宫内膜癌和不典型增生组(恶性组,n=30)、子宫内膜息肉和良性子宫内膜病变组(良性组,n=50)、正常子宫内膜(正常组,n=50)。分析3组血清脂联素与肿瘤标志物水平,分析恶性组临床病理参数和血清脂联素与肿瘤标志物水平的水平变化及意义,并统计分析脂联素与肿瘤标志物单独与联合检测的诊断效能,以病理学检查为“金标准”。结果 恶性组、良性组、正常组的血清脂联素水平[(4.51±1.03)μg/m L、(7.91±1.27)μg/m L、(12.75±2.34)μg/m L]逐渐升高,差异有统计学意义(P <0.05)。恶性组、良性组、正常组的血清癌胚抗原(carcinoembryonic antigen,CEA)、甲胎蛋白(alpha fetoprotein,AFP)、糖类抗原19-9(carbohydrate antigen 19-9,CA199)、CA153、CA125水平均逐渐降低(P <0.05)。病理分期Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者的血清脂联素水平[(5.10±1.22)μg/m L、(4.46±1.14)μg/m L、(3.74±1.23)μg/mL、(2.37±0.46)μg/mL]逐渐降低,差异有统计学意义(P <0.05)。病理分期Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者的血清AFP、CEA、CA199、CA153、CA125水平均逐渐升高,差异有统计学意义(P <0.05)。联合检测的诊断效能为96.67%、76.00%、79.23%、54.72%、98.70%,高于脂联素、肿瘤标志物单独检测的73.33%、65.00%、66.92%、38.60%、89.04%和86.67%、63.00%、68.46%、41.27%、94.03%,差异有统计学意义(P <0.05)。结论 子宫内膜病变诊断中脂联素联合肿瘤标志物检测的效能高于单独检测。Objective To explore the changes and significance of adiponectin combined with tumor markers in the diagnosis of endometrial lesions.Methods A total of 130 patients with endometrial examination in the Fourth Hospital of Baotou,Inner Mongolia Autonomous Region from January 2022 to February 2024 were retrospectively selected and divided into three groups according to disease types: endometrial cancer and atypical hyperplasia group (malignant group, n =30), endometrial polyps and benign endometrial lesions group (benign group, n =50) and normal endometrial lesion group (normal group, n =50). Serum adiponectin and tumor marker levels in the three groups were statistically analyzed, and the changes and significance of clinicopathological parameters and serum adiponectin and tumor marker levels in the malignant group were analyzed, and the diagnostic efficacy of adiponectin and tumor marker alone and combined detection was statistically analyzed, with pathological examination as the gold standard. Results The serum adiponectin levels in the malignant group, benign group, and normal group gradually increased [(4.51±1.03) μg/mL, (7.91±1.27) μg/mL, and (12.75±2.34) μg/mL], with statistically significant differences (P < 0.05). The levels of serum carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), carbohydrate antigen 19-9 (CA199), CA153, and CA125 gradually decreased in the malignant, benign, and normal groups (P < 0.05). The serum adiponectin levels of patients with pathological stages Ⅰ , Ⅱ , Ⅲ and Ⅳ gradually decreased [(5.10±1.22) μg/mL, (4.46±1.14) μ g/mL, (3.74±1.23) μ g/mL, and (2.37±0.46) μg/mL], with statistical significance (P < 0.05). The serum levels of AFP, CEA, CA199, CA153, and CA125 in patients with pathological stages Ⅰ , Ⅱ , Ⅲ and Ⅳ gradually increased, and the differences were statistically significant (P < 0.05). The diagnostic efficacy of combined testing was 96.67%, 76.00%, 79.23%, 54.72% and 98.70% higher than that of adiponectin and tumor markers alone, with 73.3

关 键 词：子宫内膜癌 脂联素 肿瘤标志物 临床病理参数 病理分期 诊断效能 

分 类 号：R737[医药卫生—肿瘤]