子宫肌瘤患者腹腔镜术后泌尿系感染病原菌分布及血清SDF-1、HMGB1早期评估价值  

Distribution of the pathogenic bacteria of women with postoperative urinary tract infection after laparoscopic surgery of uterine fibroids and the value of the levels of serum stromal cell-derived factor-1 and high mobility group protein B1 for early evalu

作　　者：黄晓敏 高月月 孙杨 史建林 HUANG Xiaomin;GAO Yueyue;SUN Yang;SHI Jianlin(Zhangjiakou Maternal and Child Health Care Hospital,Zhangjiakou,Hebei Province,O75000;The First Af filiated Hospital of Hebei North University,Zhangjiakou)

机构地区：[1]河北省张家口市妇幼保健院,075000 [2]河北北方学院附属第一医院

出　　处：《中国计划生育学杂志》2025年第4期941-945,共5页Chinese Journal of Family Planning

基　　金：河北省2024年度医学科学研究课题计划(20240056)。

摘　　要：目的:探究子宫肌瘤患者术后泌尿系感染的病原菌分布及血清基质细胞衍生因子1(SDF-1)、高迁移率族蛋白B1(HMGB1)变化及评估价值。方法:收集2022年6月-2024年3月本院腹腔镜手术治疗的子宫肌瘤患者137例为病例组,根据患者是否发生术后泌尿系感染分为感染组(36例)和未感染组(101例);同期体检健康者137例为对照组。分析各组血清SDF-1、HMGB1的水平;多因素logistic回归分析子宫肌瘤术后泌尿系感染影响因素;受试者工作特征(ROC)曲线分析血清SDF-1、HMGB1水平评估子宫肌瘤患者术后泌尿系感染发生价值。结果:137例中术后发生泌尿系感染36例,36例感染共发现45株病原菌,其中革兰阴性菌30株(66.7%),革兰阳性菌13株(28.9%),真菌2株(4.4%);病例组血清SDF-1(442.26±46.65 ng/L)、HMGB1(37.51±5.71μg/L)水平均高于对照组(337.64±38.52、23.18±3.34),且病例组术后感染患者两项指标均高于未感染患者;多因素分析,贫血、SDF-1升高、HMGB1升高为137例术后泌尿系感染发生影响因素(均P<0.05)。血清SDF-1、HMGB1水平预测子宫肌瘤术后泌尿系感染的曲线下面积(AUC)分别为0.838、0.883,二者联合诊断的AUC为0.964,高于单一指标诊断(P<0.05),此时的诊断敏感度86.1%,特异性94.1%。结论:子宫肌瘤术后泌尿系感染患者血清SDF-1、HMGB1水平均明显上调,且均为术后泌尿系感染的影响因素,二者联合检测对预测子宫肌瘤术后患者术后发生泌尿系感染有较好价值。Objective:To investigate the distribution of the pathogenic bacteria of women with postoperative urinary tract infection after laparoscopic surgery of uterine fibroids(UF)and the changes of the serum stromal cell-derived factor-1(SDF-1)and high mobility group protein B1(HMGB1)of the women,and to study the value of the SDF-1 and HMGB1 levels of the women for evaluating their urinary tract infection.Methods:137 patients with UF who had undergone the laparoscopic surgery in the hospital from June 2022 to March 2024 were included in observation group,and were divided into group A(36 cases with the postoperative urinary tract infection)and group B(101 cases without the postoperative urinary tract infection)according to whether the postoperative urinary tract infection developed or not.Another 137 healthy women who underwent physical examinations were included in control group.The levels of the serum SDF-1 and HMGB1 levels of the women in these groups were analyzed.Multivariate logistic regression was applied to analyze the factors influencing the postoperative urinary tract infection of the women with UF after surgery.Receiver operator characteristic(ROC)curve was applied to analyze the value of the serum SDF-1 and HMGB1 levels of the women with UF for their postoperative urinary tract infection.Results:In 137 women of the observation group,there were 36women with postoperative urinary tract infection.A total of 45pathogenic bacteria were found in 36women with postoperative urinary tract infection by the different pathogenic bacterias,including 30(66.7%)Gram-negative bacteria,13(28.9%)Gram-positive bacteria and 2(4.4%)fungi.The levels of the serum SDF-1(442.26±46.65ng/L)and HMGB1(37.51±5.71μg/L)of the women in the observation group were significantly higher than those(337.64±38.52ng/L and 23.18±3.34μg/L)of the women in the control group.The levels of the serum SDF-1and HMGB1of the women in group A were significantly higher than those of the women in group B.Multivariate analysis showed that the anemia,and the el

关 键 词：子宫肌瘤 腹腔镜手术 泌尿系感染 病原菌 基质细胞衍生因子1 高迁移率族蛋白B1 评估 

分 类 号：R737.33[医药卫生—肿瘤]