经颅直流电刺激对脑卒中患者下肢运动功能影响的Meta分析  

Effect of transcranial direct current stimulation on lower extremity motor function in stroke patients:a Meta-analysis

作　　者：刘语嫣 孙羽健 孙丹 赵慧 龙雨 于琼阁 温宇航 贾秋枫 余雨枫[1] LIU Yuyan;SUN Yujian;SUN Dan;ZHAO Hui;LONG Yu;YU Qiongge;WEN Yuhang;JIA Qiufeng;YU Yufeng(School of Nursing,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学护理学院,成都610075

出　　处：《数理医药学杂志》2025年第4期287-296,共10页Journal of Mathematical Medicine

摘　　要：目的系统评价经颅直流电刺激(transcranial direct current stimulation,tDCS)对脑卒中患者下肢运动功能的应用效果。方法计算机检索PubMed、Embase、Web of Science、the Cochrane Library、Scopus、中国知网、万方、维普、中国生物医学文献数据库(CBM)、Clinical Trials及中国临床试验注册中心中有关tDCS对脑卒中患者下肢功能干预的随机对照试验,检索时限为建库至2024年3月。采用Stata 17和Revman 5.4软件进行Meta分析。结果共纳入21篇文献,包含1079例脑卒中患者。Meta分析结果显示,与常规康复相比,tDCS能够改善脑卒中患者的下肢运动功能[WMD=1.99,95%CI(1.14,2.84),P<0.001]及日常生活活动能力[SMD=0.90,95%CI(0.63,1.16),P<0.001]。亚组分析结果显示,双侧刺激[WMD=2.37,95%CI(0.92,3.82),P<0.001]、干预周期>2周[WMD=2.31,95%CI(0.98,3.63),P<0.001]效果更显著。结论tDCS能够改善脑卒中患者的下肢运动功能及日常生活活动能力,建议采用双侧刺激,干预周期至少2周。Objective To systematically evaluate the effect of transcranial direct current stimulation(tDCS)on lower extremity motor function in stroke patients.Methods Randomized controlled trials of tDCS for lower extremity motor function in stroke patients were searched in PubMed,Embase,Web of Science,the Cochrane Library,Scopus,CNKI,WanFang Data,VIP,CBM,Clinical Trials and Chinese Clinical Trial Registry from the establishment of the databases to March 2024.Stata 17 and Revman 5.4 softwares were used for Meta-analysis.Results A total of 21 researches were included,including 1079 stroke patients.The results of the Meta-analysis showed that compared with conventional rehabilitation measures,tDCS can improve lower extremity motor function[WMD=1.99,95%CI(1.14,2.84),P<0.001]and activities of daily living[SMD=0.90,95%CI(0.63,1.16),P<0.001]in stroke patients.The results of subgroup analysis showed that stroke patients who accept bilateral stimulation[WMD=2.37,95%CI(0.92,3.82),P<0.001]and whose intervention period>2 weeks[WMD=2.31,95%CI(0.98,3.63),P<0.001]had more improvement.Conclusion tDCS can improve the lower extremity motor function and activities of daily living in stroke patients.Bilateral stimulation and intervention period of at least 2 weeks are recommended.

关 键 词：脑卒中 经颅直流电刺激 下肢 运动功能 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]