加味补阳还五汤治疗气虚血瘀型脑循环障碍的临床价值  

The clinical value of Jiawei Buyang Huanwu decoction in treating cerebral circulation disorders of Qi deficiency and blood stasis type

作　　者：何伟良 肖龙飞 彭乾聪 HE Weiliang;XIAO Longfei;PENG Qiancong(Department of Rehabilitation Medicine,Ji'an Traditional Chinese Medicine Hospital,Ji'an,Jiangxi,343000,China)

机构地区：[1]吉安市中医院康复医学科,江西吉安343000

出　　处：《当代医学》2025年第1期5-9,共5页Contemporary Medicine

摘　　要：目的探究加味补阳还五汤对气虚血瘀型脑循环障碍患者的治疗价值。方法选取2021年4月至2022年11月吉安市中医院收治的82例气虚血瘀型脑循环障碍患者作为研究对象,采用随机数字表法分为A组与B组,各41例。A组给予常规治疗,B组在A组基础上给予加味补阳还五汤治疗,比较两组临床疗效、脑神经功能[美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)]、纤溶指标[组织型纤溶酶原激活物(tissue-type plasminogen activator,t-PA)、t-PA抑制物(plasminogen activator inhibitor,PAI)]、脑神经损伤指标[白细胞介素-1β(interleukin-1β,IL-1β)、谷氨酸、中枢神经特异蛋白(specific protein 100β,S100β)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)]、脑循环状态[大脑中动脉(middle cerebral artery,MCA)、大脑后动脉(posterior cerebral artery,PCA)、大脑前动脉(anterior cerebral artery,ACA)收缩期峰值流速]。结果B组治疗总有效率为92.68%,高于A组的73.17%,差异有统计学意义(P<0.05)。治疗后,两组NIHSS评分均低于治疗前,且B组低于A组,差异有统计学意义(P<0.05)。治疗后,两组t-PA水平均高于治疗前,PAI水平均低于治疗前,且B组t-PA水平高于A组,PAI水平低于A组,差异有统计学意义(P<0.05)。治疗后,两组IL-1β、谷氨酸、S100β、NSE水平均低于治疗前,且B组低于A组,差异有统计学意义(P<0.05)。治疗后,两组MCA、PCA、ACA收缩期峰值流速均快于治疗前,且B组快于A组,差异有统计学意义(P<0.05)。结论加味补阳还五汤治疗气虚血瘀型脑循环障碍疗效显著,可改善患者脑神经功能和脑循环状态,减轻脑神经损伤,值得临床推广应用。Objective To explore the therapeutic value of Jiawei Buyang Huanwu decoction in patients with cerebral circulation disorders of Qi deficiency and blood stasis type.Methods 82 patients with cerebral circulation disorders of Qi deficiency and blood stasis type admitted to Ji'an Traditional Chinese Medicine Hospital from April 2021 to November 2022 were selected as the research subjects,and they were randomly divided into the group A and the group B using a random number table method,with 41 cases in each group.Group A received conventional treatment,while the group B received Jiawei Buyang Huanwu decoction on the basis of the group A.The clinical efficacy,brain nerve function(National Institute of Health stroke scale[NIHSS]),fibrinolysis indicators(tissue-type plasminogen activator[t-PA],plasminogen activator inhibitor[PAI]),brain nerve injury indicators(interleukin-1β[IL-1β],glutamate,central nervous system specific protein(S100β),neuron-specific enolase[NSE]),cerebral circulation status(the peak systolic flow velocity of middle cerebral artery[MCA],posterior cerebral artery[PCA],anterior cerebral artery[ACA])were compared between the two groups.Results The total effective rate in the group B was 92.68%,which was higher than 73.17%in the group A,and the difference was statistically significant(P<0.05).After treatment,NIHSS scores of the two groups were lower than before treatment,and group B was lower than group A,the differences were statistically significant(P<0.05).After treatment,t-PA level of the two groups was higher than before treatment,PAI level was lower than before treatment,and t-PA level in the group B was higher than that in the group A,PAI level was lower than that in the group A,the differences were statistically significant(P<0.05).After treatment,the levels of IL-1β,glutamate,S100βand NSE of the two groups were lower than before treatment,and the group B was lower than the group A,the differences were statistically significant(P<0.05).After treatment,the peak systolic flow velocity of MCA,PC

关 键 词：气虚血瘀型 加味补阳还五汤 脑神经功能 

分 类 号：R743[医药卫生—神经病学与精神病学]