热敏灸治疗仪联合乳果糖口服液对肿瘤患者化疗所致便秘的应用效果  

Application effect of heat-sensitive moxibustion therapeutic apparatus combined with lactulose oral liquid on constipation caused by chemotherapy in cancer patients

作　　者：曾莺婷 张筱雁 张群贵 赖青 李晓静 陈小妹 肖应 ZENG Yingting;ZHANG Xiaoyan;ZHANG Qungui;LAI Qing;LI Xiaojing;CHEN Xiaomei;XIAO Ying(Department of Radiotherapy,Ganzhou Cancer Hospital,Ganzhou,Jiangxi,341000,China)

机构地区：[1]赣州市肿瘤医院放疗科,江西赣州341000

出　　处：《当代医学》2025年第1期15-19,共5页Contemporary Medicine

基　　金：江西省中医药管理局科技计划(2023B0874)。

摘　　要：目的探讨热敏灸治疗仪联合乳果糖口服液对肿瘤患者化疗所致便秘的应用效果。方法选取2021年9月至2023年9月赣州市肿瘤医院诊治的80例化疗所致便秘的肿瘤患者作为研究对象,按照随机数字表法分为对照组与观察组,每组40例。对照组给予乳果糖口服液治疗,观察组在对照组基础上联合热敏灸治疗仪治疗。比较两组临床疗效、便秘症状评分、炎症因子[转化生长因子β1(transforming growth factorβ1,TGF-β1)、单核细胞趋化蛋白4(monocyte chemoattractant protein-4,MCP-4)、前列腺素E_(2)(prostaglandin E_(2),PGE_(2))]水平、生命质量评分[便秘患者生命质量量表(patient assessment of constipation quality of life,PAC-QOL)]及不良反应发生情况。结果观察组治疗总有效率为95.00%,高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗后,两组排便困难、排便时间、排便次数、粪便形状评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组TGF-β1、MCP-4、PGE_(2)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组躯体功能、心理功能、社会功能、满意度评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论热敏灸治疗仪联合乳果糖口服液治疗化疗所致便秘疗效显著,可进一步改善患者炎症因子,提高其生命质量,减轻便秘症状,且未增加患者不良反应。Objective To explore the application effect of heat-sensitive moxibustion therapeutic apparatus combined with lactulose oral liquid on constipation caused by chemotherapy in cancer patients.Methods 80 patients with constipation caused by chemotherapy diagnosed and treated in Ganzhou Tumor Hospital from September 2021 to September 2023 were selected as the research subjects,they were divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was treated with lactulose oral liquid,and the observation group was treated with heat-sensitive moxibustion therapeutic apparatus on the basis of the control group.The clinical efficacy,constipation symptom score,inflammatory factors(transforming growth factorβ1[TGF-β1],monocyte chemoattractant protein-4[MCP-4],prostaglandin E_(2)[PGE_(2)]),quality of life score(patient assessment of constipation quality of life[PAC-QOL])and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of defecation difficulty,defecation time,defecation frequency and fecal shape of the two groups were lower than those before treatment,and the observation group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,the levels of TGF-β1,MCP-4 and PGE_(2) of the two groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,the scores of physical function,psychological function,social function and satisfaction of the two groups were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adv

关 键 词：肿瘤 化疗 便秘 热敏灸治疗仪 乳果糖口服液 

分 类 号：R730.5[医药卫生—肿瘤]