经尿道激光剜除术与电切术治疗非肌层浸润性膀胱癌的疗效及并发症分析  

Analysis of curative effect and complications of transurethral laser enucleation and electrosurgical in the treatment of non-muscular invasive bladder cancer

作　　者：易琛 刘玉明[1] YI Chen;LIU Yuming(Department of Urology,Changsha Central Hospital,Changsha,Hu'nan,410000,China)

机构地区：[1]长沙市中心医院泌尿外科,湖南长沙410000

出　　处：《当代医学》2025年第1期132-135,共4页Contemporary Medicine

摘　　要：目的分析经尿道激光剜除术与电切术对非肌层浸润性膀胱癌患者疗效及并发症的影响。方法选取2020年10月至2022年7月于长沙市中心医院就诊的90例非肌层浸润性膀胱癌患者作为研究对象,根据随机数字表法分为观察组与对照组,每组45例。观察组行经尿道激光剜除术,对照组行经尿道电切术。比较两组手术相关指标、生化指标、疗效表现、并发症发生情况。结果观察组手术时间、尿管留置时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05)。治疗后,观察组白细胞计数与C反应蛋白水平均低于对照组,差异有统计学意义(P<0.05),两组红细胞计数、血红蛋白水平比较差异无统计学意义。观察组P53蛋白阳性率、Ki-67阳性率、术后2年复发率均低于对照组,无瘤生存率高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论经尿道激光剜除术治疗非肌层浸润性膀胱癌患者疗效理想,有利于缩短手术时间和尿管留置时间,改善生化指标水平,降低并发症发生率和复发率,值得临床推广应用。Objective To analyze the effect and complications of transurethral laser enucleation and electrotomy on non muscle invasive bladder cancer.Methods A total of 90 patients with non-muscle invasive bladder cancer who visited in Changsha Central Hospital from October 2020 to July 2022 were selected as the study subjects,and they were divided into the observation group and the control group according to random number table method,with 45 cases in each group.The observation group underwent transurethral laser enucleation,while the control group underwent electrosurgical resection.The surgical related indicators,biochemical indicators,efficacy performance and incidence of complications were compared between the two groups.Results The operative time and urinary catheter retention time in the observation group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group,the differences were statistically significant(P<0.05).After treatment,the white blood cell count and C-reactive protein level in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05),there were no significant diterences in red blood cell count and hemoglobin levels.The positive rate of P53 protein,Ki-67 and 2-year recurrence rate in the observation group were lower than those in the control group,and the tumor free survival rate was higher than that in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Transurethral laser enucleation is an effective method for the treatment of non-muscle invasive bladder cancer,which is beneficial to shorten the operation time and the indwelling time of the urinary tube,improve the level of biochemical indicators,reduce the rate of complications and recurrence,and is worthy of clinical promotion and application.

关 键 词：经尿道激光剜除术 电切术 非肌层浸润性膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤]