丰富环境对缺血性卒中大鼠缺血半暗带区葡萄糖代谢的影响  

Effects of enriched environment on glucose metabolism in ischemic penumbra in rats with ischemic stroke

作　　者：朱慧艳 陈敏[1] ZHU Huiyan;CHEN Min(Department of Rehabilitation Medicine,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院康复医学科,乌鲁木齐830001

出　　处：《中国医科大学学报》2025年第4期328-332,共5页Journal of China Medical University

基　　金：新疆维吾尔自治区自然科学基金(2022D01C125)。

摘　　要：目的探讨丰富环境饲养对缺血性卒中(IS)大鼠半暗带区葡萄糖代谢的影响。方法经大脑中动脉缺血构建SD大鼠IS模型,随机分组后以不同条件饲养,按计划给药,连续21 d。采用神经功能评分和TTC染色评估大鼠IS症状,采用高效液相色谱与Western blotting检测葡萄糖代谢指标与相关蛋白表达。结果与模型组相比,丰富环境组大鼠IS症状明显改善,葡萄糖代谢指标含量与相关蛋白表达增加。与阳性药组相比,阳性药+丰富环境组大鼠IS症状进一步改善,葡萄糖代谢指标与相关蛋白表达进一步提高。结论丰富环境饲养能够明显改善大鼠IS症状,其机制可能与葡萄糖代谢水平提高相关。Objective To investigate the effect of an enriched environment on glucose metabolism in the ischemic penumbra of rats with ischemic stroke(IS).Methods SD rats were subjected to middle cerebral artery ischemia to establish an IS model.The rats were randomly grouped and housed under different conditions with scheduled drug administration for 21 consecutive days.Neurological function scores and TTC staining were used to assess animal IS symptoms,whereas HPLC and Western blotting were used to detect glucose metabolic indicators and related protein expression,respectively.Results Compared to the model group,rats in the enriched environment group showed significant improvement in IS symptoms,with increased levels of glucose metabolic indicators and related protein expression.Compared to the positive drug group,rats in the positive drug+enriched environment group showed further improvement in IS symptoms,and the levels of glucose metabolic indicators and related protein expression were further enhanced.Conclusion Enriched environment can significantly improve IS symptoms in rats,and its mechanism may be related to an increase in glucose metabolic levels.

关 键 词：丰富环境 缺血性卒中 葡萄糖代谢 尼莫地平 缺血半暗带 

分 类 号：R743.3[医药卫生—神经病学与精神病学]