E1A结合蛋白P300与乳腺癌发生发展的关系研究进展  

Research progress on the relationship between E1A binding protein P300 and the development of breast cancer

作　　者：慕春燕 杨大伟 张云东 崔兆清[3] Mu Chunyan;Yang Dawei;Zhang Yundong;Cui Zhaoqing(Postgraduate School,Shandong First Medical University(Shandong Academy of Medical Sciences),Ji’nan 250117,China;Zhongyuan Institute of Biomedicine,Liaocheng City People’s Hospital,Liaocheng 252000,China;Department of Thyroid and Breast Surgery,Liaocheng City People’s Hospital,Liaocheng 252000,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)研究生部,济南250117 [2]聊城市人民医院中原生物医学研究院,聊城252000 [3]聊城市人民医院甲状腺乳腺外科,聊城252000

出　　处：《中华普通外科学文献(电子版)》2025年第2期111-115,共5页Chinese Archives of General Surgery(Electronic Edition)

基　　金：山东省医药卫生发展计划项目(202302081495)。

摘　　要：乳腺癌是女性发病率最高的恶性肿瘤之一,已成为威胁女性健康的主要杀手。乳腺癌的治疗方式包括手术、放化疗、内分泌治疗以及靶向治疗,综合治疗能够有效地延长患者生存期,但对现有化疗的耐药性越来越多。为了使患者获得更好的临床治疗结果,寻找新的治疗靶点是亟待解决的问题。E1A结合蛋白P300(EP300)是广泛表达的转录共激活因子和组蛋白乙酰化转移酶,能够乙酰化组蛋白中保守的赖氨酸残基,从而促进基因的激活转录。EP300是具有多个功能结构域的蛋白分子,能够调控多种蛋白之间的相互作用,在细胞增殖、周期调控、凋亡、DNA损伤修复和干细胞样特性等方面发挥重要而多样的生物学功能。目前EP300在乳腺癌中已被证实与肿瘤复发相关并提示不良预后,现将其与乳腺癌发生发展的关系作一综述。Breast cancer is one of the malignant tumours with the highest incidence rate among women and has become a major killer threatening women’s health.There are various treatment modalities for breast cancer,including surgery,radiotherapy,chemotherapy,endocrine therapy and targeted therapy.Combination therapy is effective in prolonging patient survival.But resistance to chemotherapy is increasing,and the search for new therapeutic targets is an urgent clinical problem in order to achieve better clinical outcomes for breast cancer patients.E1A binding protein P300(EP300)is a widely expressed transcriptional co-activator and histone acetyltransferase that acetylates conserved lysine residues in histones to promote activated transcription of genes.EP300 is a protein molecule with multiple functional structural domains that can modulate the interactions between multiple proteins.EP300 has important and diverse biological functions in cell proliferation,cell cycle regulation,apoptosis,DNA damage repair and stem cell-like properties.EP300 has now been shown to be associated with tumour recurrence in breast cancer and suggests poor prognosis.The relationship between EP300 and the development of breast cancer is now reviewed.

关 键 词：乳腺肿瘤 EIA结合蛋白P300 EP300抑制剂 

分 类 号：R737.9[医药卫生—肿瘤]