胰蛋白酶2在胰腺癌中的研究进展  

Research progress of serine protease 2 in pancreatic cancer

作　　者：李腾郝少龙 韩威[1,2] Li Teng;Hao Shaolong;Han Wei(Department of General Surgery,Beijing Luhe Hospital Affiliated to Capital Medical University,Beijing 101199,China;Central Laboratory,Beijing Luhe Hospital Affiliated to Capital Medical University,Beijing 101199,China)

机构地区：[1]首都医科大学附属北京潞河医院普外科,北京101199 [2]首都医科大学附属北京潞河医院中心实验室,北京101199

出　　处：《中华普通外科学文献(电子版)》2025年第2期115-118,共4页Chinese Archives of General Surgery(Electronic Edition)

基　　金：北京市自然科学基金资助项目(7234377)。

摘　　要：胰蛋白酶(PRSS)2是一种丝氨酸蛋白酶,通常表达于食管、胃肠及胰腺等组织器官的细胞质中,其可作为低密度脂蛋白受体相关蛋白(LRP)1配体、基质金属蛋白酶激活物以及高效消化酶激活剂,介导肿瘤免疫微环境重塑、上皮-间质转化、KRAS致癌突变及诱导胰腺炎-癌转化等多重机制,促进胰腺癌发生发展。本文通过总结PRSS2的分子结构及功能特点,并对其在胰腺癌中的相关研究进行综述,旨在为进一步探明PRSS2在胰腺癌中的作用机制提供理论参考。Serine protease 2(PRSS2)is a serine protease,which is usually expressed in the cytoplasm of cells within tissues and organs such as the esophagus,gastrointestinal tract and pancreas.It serves as a ligand for low-density lipoprotein receptor-related protein 1(LRP1),an activator of matrix metalloproteinases,and a potent activator of digestive enzymes.PRSS2 mediates multiple mechanisms,including the remodeling of the tumor immune microenvironment,epithelial-mesenchymal transition,KRAS oncogenic mutations,and the induction of pancreatic inflammation-cancer transformation,thereby promoting the occurrence and development of pancreatic cancer.This article summarizes the molecular structure and functional characteristics of PRSS2 and reviews relevant research on its role in pancreatic cancer.The aim is to provide theoretical reference for further elucidating the mechanisms of PRSS2 in pancreatic cancer.

关 键 词：胰蛋白酶2 阴离子胰蛋白酶原 肿瘤相关胰蛋白酶原-2 胰腺肿瘤 

分 类 号：R735.9[医药卫生—肿瘤]