代谢功能障碍与免疫微环境关系在肝细胞癌发生发展的作用机制  

Mechanisms of the relationship between metabolic dysfunction and immune microenvironment in the occurrence and development of hepatocellular carcinoma

作　　者：张大山 李贺鹏 蒋福林 商中华[1] Zhang Dashan;Li Hepeng;Jiang Fulin;Shang Zhonghua(Department of General Surgery,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院普通外科,太原030001

出　　处：《中华普通外科学文献(电子版)》2025年第2期124-129,共6页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：肝细胞癌(HCC)是最常见的原发性肝脏恶性肿瘤,其复杂的发病机制一直是研究的热点。随着代谢功能障碍与肿瘤免疫微环境相互作用的深入探索,越来越多的证据表明两者在肿瘤演进、免疫逃逸以及免疫治疗反应中发挥着关键作用。代谢功能障碍涉及糖酵解、氨基酸代谢等多种生化过程,在肿瘤细胞中常常发生代谢异常,以满足其快速生长和增殖的能量与物质需求,也影响了肿瘤微环境中的免疫细胞功能,从而影响其免疫应答和抗肿瘤活性。近年来,多项报道揭示了代谢功能障碍在调控HCC免疫微环境中的免疫细胞功能、免疫逃逸机制及抗肿瘤免疫反应中的重要性,但对于其如何影响免疫微环境的细胞成分及其功能,仍缺乏系统性的综述与深入分析。本研究总结代谢功能障碍与HCC免疫微环境相互作用的最新研究进展,并探讨其在免疫治疗中的潜在应用,提出可能的代谢靶点,为HCC提供了新的治疗方向和思路。Hepatocellular carcinoma(HCC)is the most common primary malignant tumor of the liver,and its complex pathogenesis has been the focus of researches.With the in-depth exploration of the interaction between metabolic dysfunction and tumor immune microenvironment,there is increasing evidence that they play a key role in tumor evolution,immune escape,and immunotherapy response.Metabolic dysfunction involves a variety of biochemical processes such as glycolysis,amino acid metabolism,which are often abnormal in tumor cells to meet the energy and material requirements of rapid growth and proliferation.At the same time,these metabolic abnormalities also affect immune cells in the tumor microenvironment,thus affecting their immune response and anti-tumor activity.In recent years,a number of reports have revealed the importance of metabolic dysfunction in regulating immune cell function,immune escape mechanism and anti-tumor immune response in the immune microenvironment of HCC.However,there is still lack of systematic review and in-depth analysis of how metabolic dysfunction affecting the cellular components and functions of the HCC immune microenvironment.This study summarizes the latest research progress on the interaction between metabolic dysfunction and HCC immune microenvironment,explores its potential application in immunotherapy,proposes possible metabolic targets,and provides new directions and ideas for future HCC treatment.

关 键 词：代谢功能障碍 代谢网络和途径 癌 肝细胞 免疫微环境 肿瘤逃逸 免疫疗法 

分 类 号：R735.7[医药卫生—肿瘤]