河南省林县食管癌高发现场防治传承研究的历史、经验、机遇和挑战  

History,Experience,Opportunities,and Challenges in Esophageal Cancer Prevention and Treatment in Linxian,Henan Province,A High Incidence Area for Esophageal Cancer

作　　者：王立东[1] 张晓倩 宋昕[1] 赵学科[1] 尤朵 雷玲玲 徐瑞华 黄金 韩文莉 王苒[1] 鲍启德[3] 纪爱芳[4] 马磊[5] 高社干[6] WANG Lidong;ZHANG Xiaoqian;SONG Xin;ZHAO Xueke;YOU Duo;LEILingling;XU Ruihua;HUANG Jin;HAN Wenli;WANG Ran;BAO Qide;JI Aifang;MA Lei;GAO Shegan(Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention&Treatment of the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China;Academy of Medical Sciences,Zhengzhou University,Zhengzhou 450052,China;Department of Oncology,Anyang District Hospital,Anyang 455000,China;Department of Clinical Laboratory,Heping Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China;Henan Provincial Key Laboratory of Tumor Molecular Biology Medicine,Nanyang First People's Hospital,Nanyang 473000,China;Department of Oncology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]郑州大学第一附属医院河南省食管癌重点开放实验室,代谢紊乱与食管癌防治全国重点实验室,郑州450052 [2]郑州大学医学科学院,郑州450052 [3]安阳地区医院肿瘤科,安阳455000 [4]长治医学院附属和平医院检验科,长治046000 [5]南阳市第一人民医院河南省肿瘤分子生物学医学重点实验室,南阳473000 [6]河南科技大学第一附属医院肿瘤科,洛阳471003

出　　处：《肿瘤防治研究》2025年第4期251-255,共5页Cancer Research on Prevention and Treatment

基　　金：国家科技重大专项(2024ZD0520900,2024ZD0520906);国家科技部国家重点研发计划“精准医学研究”重点专项(2016YFC0901403)。

摘　　要：河南省林县是中国,也是世界上食管癌发病率和死亡率最高地区之一。河南医疗队1959年进驻林县进行食管癌高发现场防治研究至今已65年。经过河南三代肿瘤医学专家坚持林县高发现场防治传承研究,目前,该地区食管鳞癌发病率下降近半,5年生存率高达40%左右,达到国际领先水平。本文旨在对林县高发现场防治的历史、机遇、挑战和防治经验(简称“林县经验”)作一探讨,为中国肿瘤防治研究提供借鉴和参考。Linxian County in Henan Province,Northern China is known as the region with the highest incidence and mortality rate of esoph-ageal cancer worldwide.Since 1959,the Henan medical team has conducted field work on esophageal cancer prevention and treatment in Linxian.Through three generations of effort exerted by oncol-ogists over 65 years of research on eso-phageal cancer prevention and treatment in Linxian,the incidence rate of esop-hageal squamous cell carcinoma in this area has dropped by nearly 50%,and the 5-year survival rate has increased to 40%,reaching the international leading level.This article aims to summarize the history,present opportunities and new challenges,and explore the experience of esophageal cancer prevention and treatment in Linxian(referred to as the“Linxian experience”),providing reference and guidance to cancer prevention and treatment research in China.

关 键 词：食管癌 林县经验 现场防治研究 食管癌高发区 

分 类 号：R735.1[医药卫生—肿瘤]