基于CiteSpace及VOSviewer的肿瘤治疗领域研究热点与趋势的可视化分析  

Visualization Analysis of Research Hotspots and Trends in Field of Tumor Therapy Based on CiteSpace and VOSviewer

作　　者：方宇航 张楚楚 隋白鹭 王妍 王润兮 陈宇 袁欣禾 杨洪军[4] 张英[1] FANG Yuhang;ZHANG Chuchu;SUI Bailu;WANG Yan;WANG Runxi;CHEN Yu;YUAN Xinhe;YANG Hongjun;ZHANG Ying(Department of Oncology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院广安门医院肿瘤科,北京100053 [2]北京中医药大学研究生院,北京100029 [3]中国中医科学院中医药信息研究所,北京100700 [4]中国中医科学院中药研究所,北京100700

出　　处：《肿瘤防治研究》2025年第4期297-304,共8页Cancer Research on Prevention and Treatment

基　　金：中国中医科学院软科学专项-中医药防治重大慢性疾病科技攻关战略研究(ZZ17-RKX-01)。

摘　　要：目的探索近10年恶性肿瘤治疗领域的研究热点及发展趋势。方法分别在中国知网、Web of Science核心合集数据库,检索近10年中英文肿瘤治疗领域相关文献,选取文献计量学的研究方法,对发表文献关键词聚类分析。结果共检索到中文文献45455篇,英文文献866958篇。结合可视化分析结果及当前肿瘤治疗的研究困境,目前国内外肿瘤治疗研究热点主要集中在四个领域:靶向治疗领域,包括药物靶点新发现、克服靶向治疗耐药、单克隆抗体及抗体-药物偶联物的开发;免疫治疗领域,重点是提高免疫检查点抑制剂应答率,解决免疫治疗耐药机制,改善治疗安全性;中医药研究领域,包括中医药治疗循证评价研究、中医药优势人群筛选及改善生活质量;新药研发领域,主要涉及类器官抗癌药物筛选、合成生物学及人工智能等前沿技术研究。结论新型靶向药物研究、免疫疗效提升、多学科交叉融合、纳米递送、中医药创新研究等是肿瘤治疗领域研究的重点方向。Objective To explore the research hotspots and development trends in the field of cancer treatment in the past decade.Methods The CNKI and Web of Science Core Collection databases were searched for Chinese and English articles related to cancer treatment published over the last 10 years.Bibliometric research methods were employed,including keyword cluster analysis of published literature.Results A total of 45455 Chinese articles and 866958 English articles were retrieved.Combining the visualization analysis results and the current research dilemma of tumor treatment revealed that the current research hotspots of tumor treatment domestically and internationally can primarily focus on four key areas.In the realm of targeted therapy,efforts are directed towards the discovery of new drug targets,overcoming resistance to targeted therapy,and the development of monoclonal antibodies and antibody–drug conjugates.In the field of immunotherapy,the emphasis lies in enhancing the response rate to immune checkpoint inhibitors,determining the mechanisms behind resistance to immunotherapy,and improving the safety of treatment.The research in traditional Chinese medicine(TCM)covers evidence-based evaluation studies on TCM treatment,the identification of populations that can gain the most benefit from TCM,and strategies for improving the quality of life.In the area of novel drug development,cutting-edge technologies,such as organoid-based screening for anticancer drugs,synthetic biology,and artificial intelligence,are under investigation.Conclusion New targeted drugs,immune efficacy improvement,multidisciplinary integration,nano-delivery,and TCM innovation are the key research directions in the field of tumor therapy in the future.

关 键 词：肿瘤治疗 靶向治疗 免疫治疗 中医药治疗 新药研发 文献计量学 

分 类 号：R730.5[医药卫生—肿瘤]