HIV/AIDS患者合并Merkel细胞多瘤病毒感染与激活的研究进展  

Research Progress on Coinfection and Activation of Merkel Cell Polyomavirus in HIV/AIDS Patients

作　　者：周显凤 齐晓彤 路亮[2] 艾勇 冯长华[2] ZHOU Xianfeng;QI Xiaotong;LU Liang;AI Yong;FENG Changhua(The Jiangxi Province Key Laboratory for Diagnosis,Treatment,and Rehabilitation of Cancer in Chinese Medicine,Cancer Research Center,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Department of HIV/AIDS,Nanchang Center for Disease Control and Prevention,Nanchang 330008,China;Department of Dermatologic Surgery,Jiangxi Provincial Hospital of Dermatology,Nanchang 330000,China)

机构地区：[1]恶性肿瘤中医药诊疗与康复江西省重点实验室,江西中医药大学癌症研究中心,南昌330004 [2]南昌市疾病预防控制中心艾滋病防制科,南昌330008 [3]江西省皮肤病专科医院皮肤外科,南昌330000

出　　处：《肿瘤防治研究》2025年第4期331-336,共6页Cancer Research on Prevention and Treatment

基　　金：江西省自然科学基金(20242BAB25355);南昌市重点专科计划(2023-2)。

摘　　要：Merkel细胞多瘤病毒(MCV)因感染人导致恶性皮肤Merkel细胞癌(MCC)而得名,属2A类致癌物。MCV通过整合T抗原基因到细胞基因组促进癌变,80%的MCC病例由MCV激活导致。普通人群MCV抗体阳性率可高达90%,通常MCV感染后处于静息潜伏状态,而器官移植、慢性淋巴细胞性白血病以及HIV感染等免疫抑制或缺陷患者MCC发生率显著升高。HIV/AIDS患者是典型的获得性免疫缺陷人群,易发生合并感染,而目前关于HIV/AIDS患者合并MCV感染、激活及致病机理的研究非常有限。为充分了解HIV合并MCV感染的疾病特征,本文对既往的MCV研究进展进行了梳理,综述了HIV感染与MCV激活的生物学特征,为AIDS等免疫功能低下的重点人群MCC的防治提供一定的参考。Merkel cell polyomavirus(MCV)was named thus because it is the causative agent of Merkel cell carcinoma(MCC),with 80%of MCC cases being MCV-positive.MCV has been classified as a 2A carcinogen.It promotes carcinogenesis by integrating T antigens into the cell genome.The anti-MCV seroprevalence in the general population is as high as 90%.Usually,MCV is latent after infection in immunocompetent patients,and the incidence of MCC in immunosuppressive or defective patients,such as those with organ transplants,chronic lymphocytic leukemia,and HIV infection,is remarkably high.Patients with HIV/AIDS are a typical population with acquired immunodeficiency.At present,the research on patients with HIV/AIDS and MCV infection,activation,and pathogenesis is limited.In this paper,the progress of previous research is reviewed and the relationship between HIV infection and MCV activation is systematically investigated to provide a reference for the prevention and treatment of MCC in key populations,such as patients with HIV/AIDS.

关 键 词：Merkel细胞多瘤病毒 HIV/AIDS 激活 MERKEL细胞癌 

分 类 号：R739.5[医药卫生—肿瘤]