放射性淋巴细胞减少症相关研究进展  

Research Development of Radiation-Induced Lymphopenia

作　　者：王玥[1] 朱辉[1] WANG Yue;ZHU Hui(Department of Oncology,The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400037,China)

机构地区：[1]重庆医科大学附属第二医院肿瘤中心,重庆400037

出　　处：《肿瘤防治研究》2025年第4期337-341,共5页Cancer Research on Prevention and Treatment

摘　　要：在放疗过程中,由于淋巴细胞具有较高的放射敏感性,许多肿瘤患者在治疗后会出现淋巴细胞数量的减少,尤其是CD8+T细胞减少,这可能会削弱其介导的抗肿瘤免疫反应。因此,放疗在激活免疫系统的同时,也可能导致一定程度的免疫抑制。当前的研究认为,放射性淋巴细胞减少(RIL)的形成机制涉及多种因素,包括淋巴细胞受到的辐射增加以及淋巴细胞毒性药物的应用。通过积极优化放射治疗剂量学参数,以最大限度地保护淋巴细胞,可以在一定程度上减轻RIL对患者临床预后的不利影响。When radiotherapy is administered,many patients exhibit a reduction in lymphocyte numbers due to the inherent radio-sensitivity of lymphocytes.In particular,they experience a decrease in CD8+T cells,which may weaken their mediated antitumor immune response.While radiotherapy activates the immune system,it can also lead to a certain degree of immunosuppression.Current research suggests that the formation mechanism of radiation-induced lymphopenia(RIL)involves multiple factors,including increased radiation exposure to lymphocytes and the application of lymphocytotoxic drugs.The adverse impact of RIL on patients’clinical outcomes can be mitigated,to some extent,by actively optimizing radiotherapy dosimetric parameters to maximally protect lymphocytes.

关 键 词：放射性淋巴细胞减少症 放射治疗 淋巴细胞绝对计数 

分 类 号：R739.41[医药卫生—肿瘤]