Not just a combination: a fully-integrated strategy of cellular therapy for acute myeloid leukemia expressing CD7, a heretofore elusive target  

作　　者：Norbert-Claude Gorin 

机构地区：[1]Department of Hematology and Cell Therapy,EBMT Global Committee and Paris Office,Hopital Saint Antoine APHP,Paris,75012,France [2]Paris Sorbonne University,Paris,75006,France

出　　处：《Science China(Life Sciences)》2025年第4期1202-1204,共3页中国科学(生命科学英文版)

摘　　要：Acute myeloid leukemia(AML) and its treatment have remained, for long, an area of slow but constant therapeutic progress as well as of permanent frustration. Chemotherapy has initially been and still is part of the backbone of therapy.However, the high rate of relapses leading to death and the development of molecular biology with recent next generation sequencing taught us that the disease is heterogeneous with often a major leukemic clone presenting frontline but always multiple clones and subclones escaping our chemotherapy regimen and generating more aggressive relapses.

关 键 词：molecular biology major leukemic clone next generation sequencing clones subclones escapin acute myeloid leukemia aml acute myeloid leukemia CD cellular therapy 

分 类 号：R733.71[医药卫生—肿瘤]