More efficient and precise:the innovation and future of probiotic delivery from the rise of intelligent self-adaptive systems  

更高效和精准:智能自适应系统兴起背景下益生菌递送的创新和未来

作　　者：Rujun Wei Xiaojun Liao Jinfeng Wang 魏汝君;廖小军;王金锋

机构地区：[1]College of Food Science&Nutritional Engineering,China Agricultural University,Beijing 100083,China

出　　处：《Science Bulletin》2025年第6期815-819,共5页科学通报(英文版)

基　　金：supported by the National Key R&D Program of China(2022YFA1304102);the National Natural Science Foundation of China(32070122,32370053,T2341010);the Chinese Universities Scientific Fund(2023RC022);Pinduoduo-China Agricultural University Research Fund(PC2023B02015);the 2115 Talent Development Program of China Agricultural University.

摘　　要：Oral intake of probiotics is one of the most popular methods to prevent and treat diseases,by inhibiting pathogen colonization and remodeling intestinal homeostasis.However,oral probiotic administration has been restricted by low bioavailability due to the acidic gastric fluid and digestive enzymes,or bile salts in the stomach and intestines,and competition with host commensal bacteria[1].It is essential to protect the viability and bioactivity of oral probiotics during the gastrointestinal(GI)tract to improve treatment effectiveness.

关 键 词：gastrointestinal tract prevent treat diseasesby oral probiotics bioavailability inhibiting pathogen colonization remodeling intestinal homeostasishoweveroral bile salts digestive enzymesor 

分 类 号：R57[医药卫生—消化系统]