Fecal microbiota transplantation:transitioning from chaos and controversial realm to scientific precision era  

肠菌移植:从混沌争议领域迈入科学精准时代

作　　者：Xinjun Wang Di Zhao Dexi Bi Long Li Hongliang Tian Fang Yin Tao Zuo Gianluca Ianiro Ning Li Qiyi Chen Huanlong Qin 王新军;赵笛;毕德玺;李龙;田宏亮;尹芳;左涛;Gianluca Ianiro;李宁;陈启仪;秦环龙

机构地区：[1]Tenth People’s Hospital of Tongji University,Shanghai 200072,China [2]Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Gusu School,Nanjing Medical University,Suzhou 215000,China [3]Department of Functional Intestinal Diseases,General Surgery of Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Shanghai 200072,China [4]Shanghai Gastrointestinal Microecology Research Center,Shanghai 200072,China [5]Shanghai Institution of Gut Microbiota Research and Engineering Development,Shanghai 200072,China [6]Clinical Research Center for Digestive Diseases,Tongji University School of Medicine,Shanghai 200072,China [7]Department of Pathology,Tenth People’s Hospital of Tongji University,Shanghai 200072,China [8]Guangdong Institute of Gastroenterology,The Sixth Affiliated Hospital of Sun Yat-sen University,Sun Yat-sen University,Guangzhou 510655,China [9]Department of Translational Medicine and Surgery,UniversitàCattolica del Sacro Cuore,Rome,00168,Italy [10]Department of Medical and Surgical Sciences,UOC Gastroenterologia,Fondazione Policlinico Universitario Agostino Gemelli IRCCS,Rome,00168,Italy [11]Department of Medical and Surgical Sciences,UOC CEMAD Centro Malattie dell’Apparato,Rome,00168,Italy

出　　处：《Science Bulletin》2025年第6期970-985,共16页科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(82300753);National Key R&D Program(2024YFA1307101);China postdoctoral science foundation(2022M722412);National Natural Science Foundation of China(82330093,81972221,and 81730102);Top priority project of Shanghai(076478684Q/2023-00154);Major project of Zhangjiang(ZJ2022-ZD-005);Clinical Research Plan of Shanghai Hospital Development Center(SHDC2020CR4026,SHDC2020CR1030B,and SHDC2022CRS041);Project of Shanghai Science and Technology Commission(YDZX20213100003690);Project of Shanghai Municipal Health Commission(19YF1431000 and ZHYY-ZXYJHZX-202105);Anhui Provincial Key R&D Programmes(202304295107020025);National Special Fund for the Construction of Key Clinical Specialties.

摘　　要：With the popularization of modern lifestyles,the spectrum of intestinal diseases has become increasingly diverse,presenting significant challenges in its management.Traditional pharmaceutical interventions have struggled to keep pace with these changes,leaving many patients refractory to conventional phar-maceutical treatments.Fecal microbiota transplantation(FMT)has emerged as a promising therapeutic approach for enterogenic diseases.Still,controversies persist regarding its active constituents,mecha-nism of action,scheme of treatment evaluation,indications,and contraindications.In this review,we investigated the efficacy of FMT in addressing gastrointestinal and extraintestinal conditions,drawing from follow-up data on over 8000 patients.We systematically addressed the controversies surrounding FMT’s clinical application.We delved into key issues such as its technical nature,evaluation methods,microbial restoration mechanisms,and impact on the host-microbiota interactions.Additionally,we explored the potential colonization patterns of FMT-engrafted new microbiota throughout the entire intestine and elucidated the specific pathways through which the new microbiota modulates host immu-nity,metabolism,and genome.

关 键 词：Fecal microbiota transplantation Gastrointestinal diseases Extraintestinal diseases Clinical research 

分 类 号：R57[医药卫生—消化系统]