circ-CCDC66联合CEA、CA19-9在结直肠癌诊断中的应用及其与临床病理特征的关系  

Application of circ-CCDC66 combined with CEA and CA19-9 in the diagnosis of colorectal cancer and its relationship with clinicopathological characteristics

作　　者：韩卓婷 林小聪 曾涛 HAN Zhuoting;LIN Xiaocong;ZENG Tao(Department of Laboratory Medicine,the Second Affiliated Hospital,the Affiliated Hospital,Guangdong Medical University,Zhanjiang 524003,Guangdong,China;Institute of Biochemistry and Molecular Biology,the Affiliated Hospital,Guangdong Medical University,Zhanjiang 524003,Guangdong,China;Center for Laboratory Medicine,the Affiliated Hospital,Guangdong Medical University,Zhanjiang 524003,Guangdong,China)

机构地区：[1]广东医科大学附属第二医院检验医学科,广东湛江524003 [2]广东医科大学生物化学与分子生物学研究所,广东湛江524003 [3]广东医科大学附属医院检验医学中心,广东湛江524003

出　　处：《中南医学科学杂志》2025年第2期260-263,共4页Medical Science Journal of Central South China

基　　金：广东省钟南山医学基金会资助项目(ZNSXS-20240012);湛江市科技计划项目(2021A05102)。

摘　　要：目的探讨环状RNA卷曲螺旋结构域蛋白66(circ-CCDC66)联合癌胚抗原(CEA)、糖类抗原19-9(CA19-9)在结直肠癌(CRC)诊断中的应用及其与临床病理特征的关系。方法选择CRC患者50例(CRC组)、肠息肉患者50例(肠息肉组)及同期体检健康者50例(对照组),比较各组circ-CCDC66、CEA、CA19-9水平,分析各指标对CRC的诊断效能。CRC组按circ-CCDC66水平分为低表达组和高表达组,比较两组临床病理特征。结果CRC组circ-CCDC66、CEA、CA19-9水平高于肠息肉组和对照组(P<0.05)。ROC曲线分析显示,circ-CCDC66、CEA、CA19-9对CRC均具有良好的诊断效能,且联合诊断效能高于单独诊断(P<0.05)。高表达组肿瘤大小≥5 cm、淋巴结转移、临床分期Ⅲ+Ⅳ期、神经侵犯的CRC患者占比高于低表达组(P<0.05)。结论circ-CCDC66、CEA、CA19-9联合诊断CRC效能高,且circ-CCDC66水平与CRC临床病理特征密切相关。Aim To investigate the application of circular RNA coiled-coil domain-containing protein 66(circ-CCDC66) combined with carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) in the diagnosis of colorectal cancer(CRC),as well as its relationship with clinicopathological characteristics.Methods A total of 50 CRC patients(CRC group),50 intestinal polyp patients(polyp group),and 50 healthy controls(control group),were selected.The levels of circ-CCDC66,CEA,and CA19-9 were compared among the groups,and the diagnostic efficacy of each indicator for CRC was analyzed.The CRC group was divided into low-expression and high-expression subgroups based on circ-CCDC66 levels,and the clinicopathological characteristics of the two subgroups were compared.Results The levels of circ-CCDC66,CEA,and CA19-9 in the CRC group were higher than those in the polyp group and the control group(P<0.05).ROC curve analysis showed that circ-CCDC66,CEA,and CA19-9 had good diagnostic efficacy for CRC,and the combined diagnostic efficacy was higher than that of individual indicators(P<0.05).The high-expression subgroup had a higher proportion of CRC patients with tumor size ≥5 cm,lymph node metastasis,clinical stage Ⅲ+Ⅳ,and neural invasion compared to the low-expression subgroup(P<0.05).Conclusion The combination of circ-CCDC66,CEA,and CA19-9 has high diagnostic efficacy for CRC,and the level of circ-CCDC66 is closely related to the clinicopathological characteristics of CRC.

关 键 词：circ-CCDC66 CEA CA19-9 结直肠癌 临床病理特征 

分 类 号：R735.3[医药卫生—肿瘤] R446.1[医药卫生—临床医学]