血清CEA、CA125、NSE、SCC、CYFRA21-1水平与肺癌患者肿瘤恶性程度及术后复发的关系分析  

Analysis of relationship between serum CEA,CA125,NSE,SCC,CYFRA21-1 levels and tumor malignancy degree and postoperative recurrence in lung cancer patients

作　　者：童列杏 李景然 刘伟 陈闫 TONG Lianxing;LI Jingran;LIU Wei;CHEN Yan(Fuyang Cancer Hospital,Fuyang 236000,Aihui,China;Hefei Maternal and Child Health Hospital,Hefei 230041,Aihui,China)

机构地区：[1]阜阳市肿瘤医院,安徽阜阳236000 [2]合肥市妇幼保健院,安徽合肥230041

出　　处：《中南医学科学杂志》2025年第2期341-344,共4页Medical Science Journal of Central South China

基　　金：安徽医科大学青年科学基金(2022xkj114)。

摘　　要：目的 分析血清肿瘤标志物癌胚抗原[(CEA)、糖类抗原125(CA125)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)]水平与肺癌患者肿瘤恶性程度及术后复发的关系。方法 选取本院收治拟行手术治疗肺癌患者188例为观察组,纳入同期良性肺部疾病患者150例为对照组。比较两组间及观察组不同肿瘤分期以及观察组复发与未复发患者血清肿瘤标志物水平;分析血清肿瘤标志物指标与肺癌患者肿瘤恶性程度的相关性以及对术后复发的预测价值。结果 观察组血清肿瘤标志物水平均高于对照组(P<0.05),且其水平随着T分期进展而升高(P<0.05),与肿瘤恶性程度呈正相关(P<0.05)。随访1年,188例肺癌术后患者中复发69例,复发组患者血清肿瘤标志物水平高于未复发者(P<0.05)。ROC曲线结果显示,血清肿瘤标志物对肺癌患者术后复发的联合预测价值高于各项指标单独预测价值(P<0.05)。结论 肺癌患者血清CEA、CA125、NSE、SCC、CYFRA21-1水平升高与肿瘤恶性程度呈正相关;并具有预测肺癌术后复发的临床价值,且其联合预测价值高于其单独预测价值。Aim To explore the relationship between levels of serum tumor markers [carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),neuron-specific enolase(NSE),squamous cell carcinoma antigen(SCC) and cyto-keratin 19 fragment antigen 21-1(CYFRA21-1)] and tumor malignancy degree and postoperative recurrence in patients with lung cancer.Methods 188 patients with lung cancer whom were scheduled to undergo surgical treatment in the hospital were enrolled as observation group,and 150 patients with benign lung diseases were included in control group.Serum tumor markers levels between both groups and among different tumor stages,as well as recurrence and non-recurvence patients in observation group were compared.The correlation between the tumor markers indicators and the degree of tumor malignancy of lung cancer patients and the predictive value on postoperative recurrence were analyzed.Results Compared with control group,the levels of serum tumor markers in observation group were higher(P<0.05).The above levels were increased with the progression of T staging(P<0.05),and were positively correlated with the degree of tumor malignancy(P<0.05).After 1 year of follow-up,69 of 188 patients with lung cancer recurred,and the levels of the tumor markers indicators in recurrence group were higher than those of non-recurrence group(P<0.05).ROC curve results showed that the predictive value of combination of tumor markers on postoperative recurrence of lung cancer patients was higher than that of single prediction(P<0.05).Conclusion The increases of serum CEA,CA125,NSE,SCC and CYFRA21-1 levels in patients with lung cancer are positively correlated with tumor malignancy degree,and have clinical value on predicting the recurrence after lung cancer surgery,with higher predictive value for the combined compared with the single.

关 键 词：肺癌 癌胚抗原 糖类抗原125 神经元特异性烯醇化酶 鳞状细胞癌抗原 细胞角质蛋白19片段抗原21-1 

分 类 号：R734.2[医药卫生—肿瘤]