肝癌肝移植术后复发影响因素及预测模型的研究进展  

Influencing factors and prediction models of hepatocellular carcinoma recurrence after liver transplantation

作　　者：秦李伟 郭亚荣[2] QIN Liwei;GUO Yarong(The First Clinical Medical College,Shanri Medical University,Taiyuan,Shanri 030001,China;Department of Oncology,the First Hospital of Shanri Medical University,Taiyuan,Shanri 030001,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院肿瘤科,山西太原030001

出　　处：《中华实用诊断与治疗杂志》2025年第3期283-288,共6页Journal of Chinese Practical Diagnosis and Therapy

基　　金：中央引导地方科技发展资金项目(YDZJSX2021A041);山西省留学人员科技活动择优资助项目(20210004);中国博士后科学基金(2021M702051)。

摘　　要：肝移植术是治疗早期肝癌、复发性肝癌、终末期肝病的有效方法,但术后5年复发率为20.0%~57.8%。肝移植术后复发的影响因素较多,除肿瘤病理特征外,还包括肝移植术式、肝炎病毒感染、肿瘤标志物水平、供肝冷缺血时间、供体选择、免疫抑制状态等因素。依据影响因素构建肝移植术后复发的预测模型,对筛选肝移植术后肝癌复发的高危人群,把握肝移植术指征具有重要意义。本文就肝癌肝移植术后复发的影响因素及预测模型的研究进展作一综述。Liver transplantation is an effective method for the treatment of early-stage hepatocellular carcinoma(HCC),recurrent HCC,and end-stage liver disease,but the postsurgical 5-year recurrence rate is 20.0%to 57.8%.The recurrence after liver transplantation is influenced by many factors,including factors such as the liver transplantation procedure,hepatitis virus infection,tumor marker levels,donor liver cold ischemia time,donor selection and immunosuppressive status in additional to tumor pathological characteristics.Constructing prediction models for recurrence after liver transplantation based on these influencing factors is of great significance for screening high-risk populations for HCC recurrence after liver transplantation and for grasping the indications of liver transplantation.This paper reviews the research progress of the influencing factors and prediction models for HCC recurrence after liver transplantation.

关 键 词：肝癌 肝移植术 复发 影响因素 预测模型 

分 类 号：R735.7[医药卫生—肿瘤]