双层探测器光谱CT定量参数预测实性肺腺癌Ki-67表达的价值  

The value of quantitative parameters of dual-layer detector spectral CT in prediction of Ki-67 expression in solid lung adenocarcinoma

作　　者：马金平 郭晓旭 王慧 雷丽敏 陶李娜 王亚婕 岳松伟[1] MA Jinping;GUO Xiaoxu;WANG Hui;LEI Limin;TAO Lina;WANG Yajie;YUE Songwei(Department of Radiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院放射科,河南郑州450052

出　　处：《实用放射学杂志》2025年第3期399-403,共5页Journal of Practical Radiology

摘　　要：目的 探讨双层探测器光谱CT(DLCT)定量参数对实性肺腺癌Ki-67表达的预测价值.方法 回顾性收集103例患者的资料,按照Ki-67增殖指数将其分为Ki-67高表达组和Ki-67低表达组.测量并计算DLCT定量参数,比较2组患者之间各参数的差异.评估差异有统计学意义的参数与Ki-67表达的相关性.采用受试者工作特征(ROC)曲线评估DLCT参数及联合参数预测实性肺腺癌Ki-67表达的效能,并采用DeLong检验进行比较.结果 长径、短径及吸烟史与实性肺腺癌Ki-67表达呈正相关(r>0,P<0.05).性别、DLCT定量参数与实性肺腺癌Ki-67表达呈负相关(r<0,P<0.05).常规+光谱CT联合参数的预测效能最高.结论 DLCT定量参数可用于评估实性肺腺癌Ki-67的表达.Objective To explore the predictive value of quantitative parameters of dual-layer detector spectral CT(DLCT)for Ki-67 expression in solid lung adenocarcinoma.Methods The data of 103 patients were retrospectively collected,and the patients were divided into Ki-67 high expression and Ki-67 low expression groups according to Ki-67 proliferation index.The quantitative parameters of DLCT were measured and calculated,and the differences in these parameters between the two groups were compared.The parameters with statistically significant differences were assessed for correlation with Ki-67 expression.The efficacy of DLCT parameters and combined parameters in predicting Ki-67 expression in solid lung adenocarcinoma were evaluated by receiver operating characteristic(ROC)curve and compared by DeLong test.Results Long diameter,short diameter and smoking history were positively correlated with the Ki-67 expression in solid lung adenocarcinoma(r>0,P<0.05).Gender and quantitative parameters of DLCT were negatively correlated with the Ki-67 expression in solid lung adenocarcinoma(r<0,P<0.05).The combined parameters of convention and spectral CT had the highest prediction efficiency.Conclusion The quantitative parameters of DLCT can be used to evaluate the Ki-67 expression in solid lung adenocarcinoma.

关 键 词：肺腺癌 KI-67 双层探测器光谱CT 

分 类 号：R734.2[医药卫生—肿瘤] R446.8[医药卫生—临床医学] R814.42