卵巢-附件报告和数据系统MRI评分联合肿瘤标志物评估卵巢肿瘤的价值  

Value of ovarian-adnexal reporting and data system MRI score combined with tumor markers in ovarian tumors

作　　者：张腊梅 孙静涛[1] 杨琦 杨淑兰 韩丽媛 ZHANG Lamei;SUN Jingtao;YANG Qi;YANG Shulan;HAN Liyuan(Department of Radiology,Tangshan Maternal and Child Health Hospital,Tangshan,Hebei Province 063000,China;Department of Clinical Laboratory,Tangshan Maternal and Child Health Hospital,Tangshan,Hebei Province 063000,China)

机构地区：[1]唐山市妇幼保健院放射科,河北唐山063000 [2]唐山市妇幼保健院检验科,河北唐山063000

出　　处：《实用放射学杂志》2025年第3期438-441,共4页Journal of Practical Radiology

基　　金：2024年河北省医学科学研究课题计划资助项目(20240605)。

摘　　要：目的 探讨卵巢-附件报告和数据系统(O-RADS)MRI评分及其联合肿瘤标志物(CA125+HE4)对卵巢肿瘤的价值.方法 回顾性分析经病理证实的223例卵巢肿瘤患者(共260个病灶)资料,用Kappa检验评估低年资医师组、高年资医师组O-RADS MRI评分的一致性,绘制受试者工作特征(ROC)曲线,分析O-RADS MRI评分及其联合肿瘤标志物(CA125+HE4)对卵巢肿瘤的诊断效能.结果 低年资医师组、高年资医师组O-RADS MRI评分的Kappa值为0.803[95%置信区间(CI)0.746~0.860];低年资医师组、高年资医师组基于O-RADS MRI评分诊断卵巢良恶性肿瘤的敏感度为0.957和0.989,特异度为0.784和0.820,准确性为0.846和0.881,阳性预测值为0.712和0.754,阴性预测值为0.970和0.993,曲线下面积(AUC)为0.871和0.905;低年资医师组、高年资医师组联合肿瘤标志物(CA125+HE4)诊断的敏感度和阴性预测值均为1.000.结论 O-RADS MRI评分对卵巢肿瘤的诊断效能高且重复性好;O-RADS MRI评分联合肿瘤标志物(CA125+HE4)可进一步提高诊断敏感度.Objective To explore the value of ovarian-adnexal reporting and data system(O-RADS)MRI score combined with tumor markers(CA125+HE4)in ovarian tumors.Methods Data from 223 patients with ovarian tumors confirmed by pathology were analyzed retrospectively,including 260 lesions.The Kappa test was used to assess the consistency of O-RADS MRI score between low and high seniority physician groups.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of O-RADS MRI score combined with tumor markers(CA125+HE4)in ovarian tumors.Results The Kappa value of the O-RADS MRI score between low and high seniority physician groups was 0.803[95%confidence interval(CI)0.746-0.860].The sensitivity based on O-RADS MRI score for distinguishing benign and malignant ovarian tumors was 0.957 and 0.989,the specificity was 0.784 and 0.820,the accuracy was 0.846 and 0.881,the positive predictive value was 0.712 and 0.754,and the negative predictive value was 0.970 and 0.993,and the area under the curve(AUC)was 0.871 and 0.905,respectively in the low and high seniority physician groups.Combined with tumor markers(CA125+HE4),the sensitivity and negative predictive value of both low and high seniority physician groups were 1.000.Conclusion The O-RADS MRI score has high diagnostic efficacy and good repeatability in ovarian tumors.Combined with tumor markers CA125 and HE4,the O-RADS MRI score can further improve the diagnostic sensitivity.

关 键 词：卵巢-附件报告和数据系统 卵巢肿瘤 磁共振成像 肿瘤标志物 

分 类 号：R737.31[医药卫生—肿瘤] R445.2[医药卫生—临床医学]