Pillararene based supramolecular nanoplatform for endoplasmic reticulum-targeting type I photodynamic and NO gas therapy  

基于柱芳烃的超分子纳米治疗平台用于内质网靶向的Ⅰ型光动力和NO气体治疗

作　　者：Shaoqi Xie Chang Liu Yue Cao Jiachen Xia Bing Lu 谢绍琦;刘畅;曹悦;夏嘉辰;卢冰

机构地区：[1]College of Chemistry and Chemical Engineering,Nantong University,Nantong 226019,China

出　　处：《Science China Materials》2025年第4期1285-1291,共7页中国科学(材料科学)(英文版)

基　　金：financially supported by the National Natural Science Foundation of China(32301184);the Universities Natural Science Research Project of Jiangsu Province(23KJB150027);the Large Instruments Open Foundation of Nantong University(KFJN2448)。

摘　　要：The development of tumor-targeted multimodality therapy is an important strategy to improve the curative effects of cancer treatment.It is critical to construct such a platform that can perfectly integrate these functional entities into one.Herein,we designed a phenyl sulfonamide-modified pillararene WP5-PEG-BSA.WP5-PEG-BSA can be used to construct endoplasmic reticulum(ER)-targeting nanocarriers.Then NO donor S-nitroso-N-acetyl-D-penicillamine(SNAP)and the newly designed photosensitizer DPP-DMATPE were loaded into the nanocarriers via different paths.Under laser irradiation,DPP-DMATPE exhibited excellent type I photodynamic activity,while SNAP can release NO under the action of glutathione.The formed nanodrugs BSA-DPP/SNAP exhibited outstanding ER-targeting and high lethality towards tumor cells as well as biocompability.What’s even more worth saying is that BSA-DPP/SNAP performed well even in hypoxic tumor cells.The final experimental results in vivo again confirmed the good therapeutic effects of BSA-DPP/SNAP.As a result,a supramolecular nanoplatform that realizes highly efficient ER-targeting type I photodynamic and NO gas cancer therapy was constructed.发展肿瘤靶向多模式联合治疗是提高肿瘤治疗疗效的重要策略.构建这样一个能够将这些功能完美集成为一体的治疗平台至关重要.本文设计合成了一种对甲基苯基磺酰胺修饰的柱芳烃WP5-PEG-BSA.WP5-PEG-BSA可用于构建内质网靶向纳米载体.然后通过不同的途径将NO供体S-亚硝基-N-乙酰青霉胺(SNAP)和新设计的光敏剂DPPDMATPE负载到纳米载体上.在激光照射下,DPP-DMATPE表现出优异的Ⅰ型光动力活性,而SNAP在谷胱甘肽的作用下可以释放NO.形成的纳米药物BSA-DPP/SNAP具有出色的内质网靶向性、对肿瘤细胞的高致死率和生物相容性.更值得一提的是,即使在缺氧的肿瘤细胞中,BSA-DPP/SNAP也表现良好.最终的体内实验结果再次证实了BSA-DPP/SNAP的良好肿瘤治疗能力.因此,本文为肿瘤高效治疗构建了一个内质网靶向的Ⅰ型光动力和NO气体协同治疗的超分子纳米平台.

关 键 词：tumor targeting therapy pillararene type I photodynamic therapy NO gas therapy 

分 类 号：R730.5[医药卫生—肿瘤]