Association between the subclinical level of problematic internet use and habenula volume:a look at mediation effect of neuroticism  

作　　者：Halwa Zakia Yusuke Kyuragi Qi Dai Naoya Oishi Yuzuki Ishikawa Lichang Yao Morio Aki Toshiya Murai Hironobu Fujiwara 

机构地区：[1]Department of Psychiatry,Kyoto University Graduate School of Medicine Faculty of Medicine,Kyoto,Japan [2]Human Brain Research Center,Kyoto University Graduate School of Medicine Faculty of Medicine,Kyoto,Japan [3]Decentralized Big Data Team,RIKENCenterforAdvanced Intelligence Project,Tokyo,Japan [4]The General Research Division,OsakaUniversityResearch Centeron Ethical,Legaland Social Issues,Osaka,Japan

出　　处：《General Psychiatry》2025年第1期26-34,共9页综合精神医学(英文)

基　　金：funded by a Grant-in-Aid for Scientific Research(B)(Japan Society for The Promotion of Science,21H02849);Grant-in-Aid for Scientific Research(C)(Japan Society for The Promotion of Science,23K07013);Grant-in-Aid for Transformative Research Areas(A)(Japan Society for The Promotion of Science,JP21H05173);Grant-in-Aid by the Smoking Research Foundation;Grant-in-Aid by the Telecommunications Advancement Foundation.

摘　　要：Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.

关 键 词：internet use piu hb volumetry Mediation Effect Habenula Volume NEUROTICISM personality traits Subclinical Level Problematic Internet Use 

分 类 号：R749.5[医药卫生—神经病学与精神病学]