内蒙古某省级三甲医院2015-2022年成人急性淋巴细胞白血病发病情况分析  

Analysis of the Incidence of Adult Acute Lymphoblastic Leukemia in a Provincial Tertiary Hospital in Inner Mongolia over 8 years

作　　者：周倩 曹志凤 李艳敏 金阿荣 Zhou Qian;Cao Zhifeng;Li Yanmin;Jing Arong(Department of Hematology,Inner Mongolia People's Hospital,Hohhot 010017,Inner Mongolia Autonomous Region,China;不详)

机构地区：[1]内蒙古自治区人民医院血液内科,内蒙古自治区呼和浩特市010017 [2]内蒙古自治区第四医院呼吸内科,内蒙古自治区呼和浩特市010000

出　　处：《中国病案》2025年第3期58-61,64,共5页Chinese Medical Record

基　　金：内蒙古自治区人民医院院内基金项目(2022YN17);内蒙古自治区自然科学基金项目(2024LHMS08072);2022年度内蒙古自治区卫生健康科技计划项目(202201056)。

摘　　要：目的了解内蒙古某省级三甲医院8年初发成人急性淋巴细胞白血病患者的发病情况,分析流行病学特征。为血液病的危险因素及发病机制研究提供参考。方法回顾性分析2015年1月1日—2022年12月31日在某院血液内科收治的102例初发成人急性淋巴细胞白血病患者的发病年龄、性别、地域分布、发病季节、发病初症状、发病诱因、疾病分型、免疫学分型、染色体、融合基因等情况,采用χ^(2)检验,进行统计学比较。结果初发成人急性淋巴细胞白血病患者中男女发病人数无明显差异,59~68岁年龄段人数最多,发病人数37例,占36.27%,发病人数多于其他年龄组,有统计学差异。59岁以上患者54人,占总人数的37.17%,可见随年龄增长,发病人数增多。性别无明显差异;农牧区患者多于城市;化学物质等接触史、家族肿瘤史可能对疾病的发生有一定影响;发病季节高峰为9-11月的秋冬季节;发热为主要的临床表现;危险度分型以中危型为主占59.80%,其中B-ALL 56.86%和T-ALL 2.94%,不同分型患者危险度分型差异有统计学意义;形态学分型L1型为主,占55.88%,免疫学分型以B-ALL为主,占94.12%;最常见的染色体结构畸变为t(9:22)(即Ph染色体),共18例,总发生率为17.65%,49~58岁患者Ph阳性发病率最高,59岁以下患者有随年龄增长而增多的趋势。结论房屋装修史、有毒化学物质接触史、居家环境存在污染源等暴露因素可能为诱发急性淋巴细胞白血病的危险因素。家族肿瘤史、细胞遗传学类型、融合基因、危险度的分层可能为影响急性淋巴细胞白血病预后的重要因素,调查结果为该地区白血病的防治提供了依据。Objectives This study aims to understand the incidence of adult acute lymphoblastic leukemia in a provincial tertiary hospital in Inner Mongolia for 8 years and analyze the epidemiological characteristics.Methods A retrospective analysis was performed on 102 patients with newly diagnosed adult acute lymphoblastic leukemia who were admitted to the Department of Hematology of a certain hospital from January 1,2015 to December 31,2022,with respect to age,gender,geographical distribution,season of onset,initial symptoms,causes of onset,disease classification,immunological classification,chromosome,fusion gene,etc.,and statistical comparison was performed.Results There was no significant difference in the number of male and female patients with first-onset adult acute lymphoblastic leukemia.The largest age group was 59 to 68 years old,with 37 cases,accounting for 36.27%,which was more than that in other age groups,with a statistically significant difference.There were 54 patients aged 59 and above,accounting for 37.17% of the total number.The number of patients increased with age.There was no significant difference in gender;There were more patients in farming and pastoral areas than in cities;History of exposure to chemical substances and family history of tumors might have a certain impact on the occurrence of the disease;The peak season for onset was the autumn and winter season from September to November;Fever was the main clinical manifestation.The risk classification was mainly intermediate-risk type,accounting for 59.80%,including 56.86% of B-ALL and 2.94% of T-ALL.The risk classification of patients with different types was statistically significant.The morphological classification was mainly L1 type,accounting for 55.88%,and the immunological classification was mainly B-ALL,accounting for 94.12%.The most common chromosomal structural aberration was t(9∶22)(i.e.,Ph chromosome),with a total of 18 cases and a total incidence of 17.65%.The highest incidence of Ph-positive was in patients aged 49 to 58 years,and

关 键 词：急性淋巴细胞白血病 成人 内蒙古呼和浩特 流行病学 防治疾病 

分 类 号：R733.71[医药卫生—肿瘤]