内镜下贲门部金属夹联合套扎治疗难治性胃食管反流病的近期疗效  

Short-term Efficacy of Endoscopic Cardia Metal Clip Combined with Band Ligation in the Treatment of Refractory Gastroesophageal Reflux Disease

作　　者：陈卓锋 徐娟 黄筱霞 陈丽萍 陈宝桢 Chen Zhuofeng;Xu Juan;Huang Xiaoxia;Chen Liping;Chen Baozhen(Shunde Hospital Affiliated to Guangzhou Medical University,Foshan 528315,Guangdong Province,China;不详)

机构地区：[1]广州医科大学附属顺德医院,广东省佛山市528315

出　　处：《中国病案》2025年第3期106-109,共4页Chinese Medical Record

基　　金：广东省佛山市科技创新项目(2220001004138)。

摘　　要：目的研究内镜下贲门部金属夹联合套扎治疗难治性胃食管返流病rGERD的近期疗效,为临床治疗rGERD提供方案选择。方法选择从2021年3月1日—2024年3月1日在某院接受治疗的rGERD患者98例作为观察对象。通过随机数表法划分成观察组及对照组各49例,对照组使用传统PPIs药物治疗,观察组使用内镜下贲门部金属夹联合套扎术治疗。随访3个月,对比2组近期疗效,GERD-HRQL及GERD-Q评分,PGⅠ、PGⅡ及G-17水平,以及并发症。结果观察组的总有效率是97.96%(48/49),高于对照组的79.59%(39/49)。组间比较2组治疗前的GERD-HRQL及GERD-Q评分相比,差异不显著。观察组治疗后的GERD-HRQL(6.24±1.36)分及GERD-Q评分(2.47±0.68)分低于对照组(10.33±2.47)分、(4.33±1.25)分。组内比较2组治疗后的GERD-HRQL及GERD-Q评分低于治疗前。组间比较2组治疗前的PGⅠ、PGⅡ及G-17水平相比,差异不显著。观察组治疗后的PGⅠ(66.77±15.74)μg/L、PGⅡ(14.35±3.29)μg/L及G-17水平(5.26±1.35)μg/L低于对照组(78.26±16.32)μg/L、(18.76±4.37)μg/L、(8.49±2.37)μg/L。组内比较2组治疗后的PGⅠ、PGⅡ及G-17水平低于治疗前。观察组并发症的总发生率是16.33%,与对照组的6.12%比较,差异不显著。结论内镜下贲门部金属夹联合套扎治疗r GERD患者的近期疗效较好,可改善食管及胃肠道的综合运动功能及临床症状,安全性较高,值得推广。Objectives This study aims to investigate the short-term efficacy of endoscopic cardia metal clip combined with band ligation in the treatment of rGERD,in order to provide a treatment option for clinical rGERD.Methods A total of 98 patients with rGERD who were treated in a hospital from March 1,2021 to March 1,2024 were selected as the observation subjects.The patients were randomly divided into an observation group and a control group with 49 cases in each group.The control group was treated with traditional PPIs,while the observation group was treated with endoscopic cardia metal clip combined with band ligation.The patients were followed up for 3 months,and the short-term efficacy,GERD-HRQL and GERD-Q scores,PGⅠ,PGⅡ and G-17 levels,and complications were compared between the two groups.Results The total effective rate of the observation group was 97.96%(48/49),which was higher than 79.59%(39/49)of the control group.When comparing the GERD-HRQL and GERD-Q scores between the two groups before treatment,no significant difference was found.After treatment,the GERD-HRQL(6.24±1.36)and GERD-Q scores(2.47±0.68)in the observation group were lower than those in the control group(10.33±2.47)and(4.33±1.25).Intra-group comparison showed that the GERD-HRQL and GERD-Q scores after treatment were lower than those before treatment.When comparing the pre-treatment levels of PGⅠ,PGⅡ,and G-17 between the two groups,no significant difference was found.After treatment,the levels of PGⅠ(66.77±15.74μg/L),PGⅡ(14.35±3.29μg/L)and G-17(5.26±1.35μg/L)in the observation group were lower than those in the control group(78.26±16.32μg/L,18.76±4.37μg/L,and 8.49±2.37μg/L,respectively).Intra-group comparison showed that the levels of PGⅠ,PGⅡ and G-17 in the two groups after treatment were lower than those before treatment.The total incidence rate of complications was 16.33%in the observation group and 6.12% in the control group;however,the difference was not significant.Conclusions Endoscopic cardia metal clip com

关 键 词：内镜下贲门部金属夹 联合套扎 难治性胃食管反流病 近期疗效 

分 类 号：R571[医药卫生—消化系统]