基于孟德尔随机化探讨4种脂质成分与早期年龄相关性黄斑变性的关系  

Relationship Between Four Lipid Components and Early Age-Related Macular Degeneration Based on Mendelian Randomization

作　　者：郑春燕 南安超[1] ZHENG Chunyan;NAN Anchao(Ophthalmology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第二附属医院眼科,河南郑州450000

出　　处：《河南医学研究》2025年第8期1345-1351,共7页Henan Medical Research

摘　　要：目的 采用两样本孟德尔随机化(MR)方法分析血液中的4种脂质成分[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)]与早期年龄相关性黄斑变性(AMD)的因果关系。方法 本研究提取全基因关联研究(GWAS)数据库,选择与4种脂质成分密切相关的遗传位点作为工具变量,以逆方差加权(IVW)法作为主要分析方法,同时辅以加权中位数(WME)、MR-E_(gger)回归法、简单模式法和加权模式法对数据进行两样本MR分析。评价4种脂质成分与早期AMD患病风险间的因果关系,OR值作为评价指标。为保证结果的可靠性和稳定性,同时进行了异质性检验、基因多效性检验和敏感性分析。结果 HDL-C可增加早期AMD的患病风险(OR=1.21,95%CI:1.11~1.31,P<0.05),其他3种脂质TC、TG、LDL-C与早期AMD的患病风险间无相关性(OR<1,P<0.05)。结论 HDL-C可能增加早期AMD的患病风险,提示可对早期AMD患者的HDL-C水平进行监测,并为进一步明确AMD的发病机制提供新的研究视角。Objective To analyze the relationship between four lipid components[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]in blood and early age-related degeneration of macula(AMD)by using a two sample Mendelian randomization(MR)method.Methods This study searched the genome-wide association study(GWAS)database and selected genetic loci closely related to four lipid components as instrumental variables.The inverse variance weighted(IVW)method was used as the main method,and weighted median(WME),MR Egger regression,simple single mode method,and weighted mode method were used as auxiliary methods to perform two sample MR analysis on the data.Evaluate the relationship between four lipid components and early AMD,using OR values as evaluation indicators.To ensure the reliability and stability of the results,heterogeneity tests,gene pleiotropy tests,and sensitivity analyses were simultaneously carried out.Results The results showed that HDL-C could increase the risk of early AMD(OR=1.21,95%CI:1.11~1.31,P<0.05),while there was no correlation between the other three lipids TC,TG,LDL-C with the risk of early AMD(OR<1,P<0.05).Conclusion HDL-C may increase the risk of early AMD,suggesting that we can monitor the HDL-C levels of early AMD patients and provide a new research perspective for us to further clarify the pathogenesis of AMD.

关 键 词：年龄相关性黄斑变性 早期 孟德尔随机化 甘油三酯 总胆固醇 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 

分 类 号：R774.5[医药卫生—眼科]