交替区域入肝血流阻断对腹腔镜肝切除患者术后肝功能、血清CXCL8、CXCR2水平的影响  

Effects of Alternate Regional Hepatic Inflow Occlusion on Liver Function,Serum CXCL8 and CXCR2 Levels in Patients Undergoing Surgery After Laparoscopic Hepatectomy

作　　者：门中俊 侯潇峰 孙万日[1] MEN Zhongjun;HOU Xiaofeng;SUN Wanri(Minimally Invasive Surgery of General Surgery,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院普通外科微创外科,河南南阳473000

出　　处：《河南医学研究》2025年第8期1469-1472,共4页Henan Medical Research

摘　　要：目的 探究交替区域入肝血流阻断对腹腔镜肝切除患者术后肝功能及血清CXC趋化因子配体8(CXCL8)、CXC趋化因子受体2(CXCR2)水平的影响。方法 择取南阳市中心医院2021年6月至2022年10月收治的肝癌患者64例,按照抽签法分为传统组(32例,接受传统阻断,即Pringle法)与研究组(32例,接受交替区域入肝血流阻断)。对比各组手术相关、肝功能、免疫功能、血清CXCL8、CXCR2水平等指标。结果 对比传统组,研究组术中出血量少、住院时间短(P<0.05),术后3 d总胆红素(TBIL)、谷丙转氨酶(GPT)、谷草转氨酶(GOT)低(P<0.05),CD3^(^(+))、CD4^(+)高(P<0.05),CD8^(+)及术后3个月血清CXCL8、CXCR2水平低(P<0.05)。两组术后3个月死亡、并发症差异无统计学意义(P>0.05)。结论 交替区域入肝血流阻断能明显减少腹腔镜肝切除术中出血量,对患者肝功能、免疫功能影响小,且能降低血清CXCL8、CXCR2水平,有利于预后。Objective To explore the effects of alternate reginal hepatic inflow occlusion on liver function,serum CXC chemokine ligand 8(CXCL8),CXC chemokine receptor 2(CXCR2)levels in patients with laparoscopic hepatectomy.Methods A total of 64 patients with liver cancer admitted to Nanyang Central Hospital from June 2021 to October 2022 were selected and divided into the conventional group(32 cases,received conventional occlusion,Pringle method)and the study group(32 cases,received alternate reginal hepatic inflow occlusion)by lot.Surgical correlation,liver function immune function,serum CXCL8 and CXCR2 levels were compared in each group.Results Compared with those in the conventional group,the amounts of intraoperative blood loss and length of hospital stay in the study group were less(P<0.05),and the postoperative 3 d total bilirubin(TBIL),glutamic-pyruvic transaminase(GPT)and glutamic-oxaloacetic transaminase(GOT)were lower(P<0.05).CD3^(+)and CD4^(+)were higher 3 d after the surgery(P<0.05),and levels of CD8^(+)and serum CXCL8 and CXCR2 were lower 3 months after the surgery(P<0.05).There was no difference in death and complications three months after surgery between the two groups(P>0.05).Conclusion Alternate regional hepatic inflow occlusion can significantly reduce the amount of intraoperative blood loss during laparoscopic hepatectomy,have little effect on liver function and immune function of patients,and can significantly reduce the levels of serum CXCL8 and CXCR2,which is conducive to prognosis.

关 键 词：肝癌 交替区域入肝血流阻断 肝功能 免疫功能 CXC趋化因子配体8 CXC趋化因子受体2 

分 类 号：R735.7[医药卫生—肿瘤]