洛铂与顺铂联合氟尿嘧啶对胃肠道肿瘤肝转移介入治疗患者疼痛及癌因性疲乏的影响  

Effect of Combination Therapy of Lobaplatin and Cisplatin with Fluorouracil on Pain and Cancer-Related Fatigue in Patients Undergoing Interventional Treatment for Liver Metastasis of Gastrointestinal Tumors

作　　者：赵青 ZHAO Qing(Department of Pharmacy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院药剂科,河南郑州450000

出　　处：《河南医学研究》2025年第8期1500-1503,共4页Henan Medical Research

摘　　要：目的 探讨氟尿嘧啶分别与洛铂或顺铂联合对胃肠道肿瘤肝转移介入患者的治疗情况。方法 纳入在郑州大学第一附属医院实施介入治疗的62例胃肠道肿瘤肝转移患者,根据介入用药方案分为对照组(30例)、观察组(32例),前者采用顺铂联合氟尿嘧啶,后者采用洛铂联合氟尿嘧啶。观察两组患者短期内疗效、疼痛、癌因性疲乏、1 a内生存率、无进展生存率以及药物毒性反应。结果 相较对照组,观察组短期内疗效更高,差异有统计学意义(P<0.05)。治疗后,观察组癌因性疲乏评分、疼痛度较对照组更低,差异有统计学意义(P<0.05)。随访1 a,观察组生存率及无进展生存率较对照组有所降低,但差异无统计学意义(P>0.05)。观察组神经毒性反应、血小板减少症低于对照组,差异有统计学意义(P<0.05);其余毒性反应组间对比,差异无统计学意义(P>0.05)。结论 与顺铂相比,采用洛铂联合氟尿嘧啶联合方案,对胃肠道肿瘤肝转移介入治疗患者更具效果,对延长患者生存时间、控制病情进展具有积极作用,药物毒性反应中,患者出现血小板减少、肾功能损害的风险显著下降,值得推广。Objective To explore the treatment of fluorouracil combined with loplatin or cisplatin in patients with liver metastasis of gastrointestinal tumors.Methods A total of 62 patients with gastrointestinal tumor liver metastasis who received interventional therapy admitted to the First Affiliated Hospital of Zhengzhou University.According to the interventional scheme,the patients were divideded into control group(30 cases)and the observation(32 cases)group,the former using cisplatin combined with fluorouracil,the latter using platinum combined with fluorouracil.The short term efficacy,pain,cancer due to fatigue,1 year survival rate,progression-free survival rate and drug toxicity were observed in the two groups.Results Compared with the control group,the observation group had a higher short-term therapeutic effect,and there was a significant difference between the groups(P<0.05).After treatment,the cancer-related fatigue score and pain level in the observation group were lower than those in the control group,with significant differences(P<0.05).Follow up for 1 year showed that the survival rate and progression free survival rate of the observation group were lower than those of the control group,but the difference was not statistically significant(P>0.05).The neurotoxic reactions and thrombocytopenia in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the comparison of other toxic reactions between groups(P>0.05).Conclusion Compared with cisplatin,the combination of loplatin and fluorouracil is more effective for patients with gastrointestinal tumor and liver metastasis,and has a positive effect on prolonging the survival time and controlling the progression of the disease.During drug toxicity,the risk of thrombocytopenia and renal impairment is significantly decreased,which is worth promoting.

关 键 词：胃肠道肿瘤 肝转移 洛铂 顺铂 氟尿嘧啶 介入治疗 毒性反应 

分 类 号：R735[医药卫生—肿瘤]