HPV-16、HPV-58亚型与宫颈癌及癌前病变发病风险的关系  

Relationship between HPV-16,HPV-58 subtypes and the risk of cervical cancer and precancerous lesions

作　　者：薛玲玲[1] 马会峰[2] 霍明珠 赵丹丹 杨夏楠[1] Xue Lingling;Ma Huifeng;Huo Mingzhu;Zhao Dandan;Yang Xianan(Department of Gynecology,the First Afiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Department of Obstetrics,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院妇科病区,河南洛阳471000 [2]河南科技大学第一附属医院产科,河南洛阳471000

出　　处：《临床医学》2025年第3期12-15,共4页Clinical Medicine

摘　　要：目的 探讨人乳头瘤病毒(HPV)-16、HPV-58亚型与宫颈癌及癌前病变发病风险的关系。方法 选取2022年1月至2023年12月在河南科技大学第一附属医院就诊的180例高危型HPV感染者作为研究对象,分别为慢性宫颈炎60例、宫颈上皮内瘤变58例、宫颈癌62例。检测患者HPV-16和HPV-58的分布情况。采用Logistic分析HPV-16和HPV-58与宫颈癌之间的相关性,使用ROC曲线分析其对宫颈癌的诊断价值。结果 HPV-16在宫颈炎、宫颈上皮内瘤变以及宫颈癌中的阳性率依次为13.33%、27.58%、40.32%,感染率呈逐渐升高趋势,差异有统计学意义(P<0.05)。HPV-58在宫颈炎、宫颈上皮内瘤变以及宫颈癌中的阳性率依次为8.33%、15.52%、29.03%,感染率呈逐渐升高趋势,差异有统计学意义(P<0.05)。单因素、多因素Logistic回归分析显示,HPV-16和HPV-58是导致宫颈癌病理进展的独立危险因素(P<0.05)。ROC曲线分析显示,HPV-16、HPV-58诊断宫颈癌变的AUC分别为0.858(95%CI:0.803~0.914),0.893(95%CI:0.848~0.938)。结论 宫颈癌和癌前病变的发生与高危型HPV的持续感染密切相关。不同高危型HPV导致宫颈癌及癌前病变的风险不同,对异常HPV筛查结果应根据其致病风险进行分层管理。Objective To investigate the relationship between human papilloma virus(HPV)-16,HPV-58 subtypes and the risk of cervical cancer and precancerous lesions.Methods Atotal of 180 patients with high-risk HPV infection who were treated in the First Affiliated Hospital ofHenan University of Science and'Technology from January 2022 to December 2023 were selected as thestudy subjects,including 60 cases of chronic cervicitis,58 cases of cervical intraepithelial neoplasia,and62 cases of cervical cancer.The distribution of HPV-16 and HPV-58 in the patients were detected.Thecorrelation of HPV-16 and HPV-58 with cervical cancer was analyzed by Logistic regression model,andtheir diagnostic value for cervical cancer was analyzed by ROC curve.ResultsThe positive rate ofHPV-16 in cervicitis,cervical intraepithelial neoplasia and cervical cancer was 13.33%,27.58%and40.32%,respectively,and the infection rate showed a gradually increasing trend,with significantdifferences(P<0.05).The positive rate of HPV-58 in cervicitis,cervical intraepithelial neoplasia andcervical cancer was 8.33%,15.52%and 29.03%,respectively,and the infection rate showed agradually increasing trend,the differences were significant(P<0.05).Univariate and multivariateLogistic regression analysis showed that HPV-16 and HPV-58 were independent risk factors for thepathological progression of cervical cancer(P<0.05).ROC curve analysis showed that,the AUC ofHPV-16 and HPV-58 for diagnosis of cervical cancer were 0.858(959%C1:0.803-0.914)and 0.893(95%Cl:0.848-0.938),respectively.Conclusions The occurrence of cervical cancer and precancerous lesions is closely related to the sustained infection of high-risk HPV.The risk of cervical cancer and precancerous lesions caused by different high-risk HPV types varies,and the screening results of abnormal HPV should be stratified and managed based on their pathogenic risk.

关 键 词：高危型HPV 持续感染 宫颈癌 宫颈癌前病变 

分 类 号：R737.33[医药卫生—肿瘤]