基于“线粒体-神经炎症”损伤机制从“痰”论治阿尔茨海默病  

Treatment of Alzheimer's Disease from"Phlegm"Based on Damage Mechanism of"Mitochondria-Neuroinflammation"

作　　者：李鹏程 程美佳 鞠业涛 刘勇明[2] 袁常斌 史宝瑞 杨雅丽 于畅洋 张力[1] 闵冬雨[2] LI Pengcheng;CHENG Mejia;JU Yetao;LIU Yongming;YUAN Changbin;SHI Baorui;YANG Yali;YU Changyang;ZHANG Li;MIN Dongyu(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《实用中医内科杂志》2025年第4期56-60,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金面上项目(82174114,81974548);辽宁省科学技术厅自然基金指导项目(2019-ZD-0965);辽宁中医药大学中医脏象理论及应用教育部重点实验室开放基金项目(zyzx2006);辽宁中医药大学省重点实验室后补助项目(2100220171);沈阳市科技计划项目(20-205-4-008)。

摘　　要：近年来,阿尔茨海默病(Alzheimer’s disease,AD)的诸多研究进展为相关研究领域提供了新的研究视角,随着AD在遗传学和发病机制研究领域的持续深化,其中以线粒体和神经炎症之间的关系为突破口取得了关键性突破,细胞内的线粒体是能量代谢中枢,AD患者神经细胞内线粒体动力学和自噬改变,可以引起线粒体功能障碍,引发线粒体内氧化应激增强、释放线粒体成分以及线粒体自噬,诱导神经炎性反应发生,炎性反应可引起神经细胞凋亡,进而引发功能障碍加剧AD。该文通过研究国内外线粒体-神经炎症-AD损伤机制的文献报道,在与中医学中老年痴呆的痰浊相结合,进而建立“线粒体-神经炎症-AD”中西医结合病理理论,从痰论治,在此基础上,深入探讨AD新的治疗机制。In recent years,many research advances in Alzheimer's disease(AD)have given a glimmer of hope to the academic community,with the continuous in-depth exploration and innovation of AD in the direction of genetics and pathogenesis.Among them,the relationship between mitochondria and neuroinflammation has been made as a breakthrough,the mitochondria in the cell are the center of energy metabolism,and the changes in mitochondrial dynamics and autophagy in nerve cells in AD patients can cause mitochondrial dysfunction,trigger the enhancement of oxidative stress in the mitochondria,release mitochondrial components and mitophagy,and induce the occurrence of neuroinflammatory reactions,which can cause apoptosis of nerve cells,and then cause dysfunction to aggravate AD.In this paper,it studyed the literature reports on the mechanism of mitochondria,neuroinflammation and AD damage at home and abroad,and combined the phlegm turbidity factors of AD in traditional Chinese medicine,and then established the pathological theory of"phlegm turbidity-mitochondria-neuroinflammation-AD"integrated with traditional Chinese and Western medicine.On this basis,it deeply explored the new treatment mechanism of AD.

关 键 词：阿尔茨海默病 痰浊 线粒体 神经炎症 

分 类 号：R749.16[医药卫生—神经病学与精神病学]