糖尿病性视网膜病变发病相关非编码RNAs的研究进展  

Research Progress of Non-coding RNAs Related to the Pathogenesis of Diabetic Retinopathy

作　　者：雒文娟[1] 于麦霞 董文萍 LUO Wenjuan;YU Maixia;DONG Wenping(Department of Ophthalmology,the Second Hospital of Lanzhou University/the Second Clinical Medical College,Lanzhou University,Lanzhou 730030,Gansu,China)

机构地区：[1]兰州大学第二医院/兰州大学第二临床医学院眼科,甘肃兰州730030

出　　处：《医学信息》2025年第7期172-176,共5页Journal of Medical Information

基　　金：甘肃省科技计划项目(自然科学基金)(编号:22JR5RA992)。

摘　　要：糖尿病性视网膜病变(DR)是一种由于葡萄糖代谢异常引起的进行性致盲性疾病。近年来,大量研究表明非编码RNA(ncRNA)如mi RNA、lncRNA、和circRNA与DR的氧化应激、血管异常等发病机制密切相关,并可以作为DR相关标志物和治疗靶点。本文综述了nc RNA表达失调与DR进展的相关研究,并提出对该领域的未来展望。Diabetic retinopathy(DR) is a progressive blinding disease caused by abnormal glucose metabolism.In recent years,a large number of studies have shown that non-coding RNAs(ncRNAs) such as miRNA,lncRNA,and circRNA are closely related to the pathogenesis of DR,such as oxidative stress and vascular abnormalities,and can be used as DR-related markers and therapeutic targets.This article reviews the research progress of nc RNA expression disorders and DR,and proposes future prospects in this field.

关 键 词：糖尿病性视网膜病变 氧化应激 NCRNA 生物标志物 治疗靶点 

分 类 号：R774.1[医药卫生—眼科] R587.2[医药卫生—临床医学]