miRNAs在卵巢癌发病机制和治疗耐药中的作用  

Role of miRNAs in the Pathogenesis and Treatment Resistance of Ovarian Cancer

作　　者：王芳 杨永秀[1,2,3] WANG Fang;YANG Yongxiu(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,Gansu,China;Department of Obstetrics and Gynecology,the First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China;Gansu Province Gynecological Tumor Clinical Research Center,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院妇产科,甘肃兰州730000 [3]甘肃省妇科肿瘤临床研究中心,甘肃兰州730000

出　　处：《医学信息》2025年第7期187-192,共6页Journal of Medical Information

基　　金：兰州大学医学教育创新发展项目(编号:lzuyxcx-2022-200)。

摘　　要：卵巢癌(OC)是妇科癌症死亡的主要原因,OC早期无症状,晚期疾病症状无特异性。因此,超过75%的OC病例被诊断为晚期。据报道,mi RNA等多种表观遗传因素会影响OC方面,包括起始、进展、血管生成和对治疗的耐药性。mi RNAs可以调控参与OC发病机制的多种基因的表达。这种作用归因于mi RNA在起始、增殖、转移中的作用。mi RNA还影响关键的OC相关机制通路,例如JAK/STAT轴、NF-κB信号、MAPK信号通路、PI3K/AKT信号通路,除了发病机制外,mi RNA还可能影响OC对化疗的反应和对肿瘤细胞的生物学过程。基于此,本文拟阐明mi RNAs与OC之间的联系,重点关注mi RNA对OC信号通路的影响。Ovarian cancer(OC) is the main cause of death in gynecological cancer.OC is asymptomatic in the early stage and has no specific symptoms in the late stage.Therefore,more than 75% of OC cases are diagnosed as advanced stage.It has been reported that a variety of epigenetic factors such as miRNAs can affect OC,including initiation,progression,angiogenesis,and resistance to treatment.MiRNAs can regulate the expression of multiple genes involved in the pathogenesis of OC.This effect is attributed to the role of miRNA in initiation,proliferation,and metastasis.MiRNAs also affect key OC-related mechanism pathways,such as JAK/STAT axis,NF-κB signaling,MAPK signaling pathway,PI3K/AKT signaling pathway.In addition to the pathogenesis,mi RNAs may also affect the response of OC to chemotherapy and the biological process of tumor cells.Based on this,this paper intends to clarify the relationship between miRNAs and OC,focusing on the effect of miRNAs on OC signaling pathway.

关 键 词：耐药性 卵巢癌 发病机制 微小核糖核酸 

分 类 号：R737.31[医药卫生—肿瘤]