灼口综合征患者睡眠质量特点及其影响因素初步分析  

Characteristics of sleep quality and influencing factors in patients with burning mouth syndrome:a preliminary analysis

作　　者：卢成辉 杨成龙 周璇[2] 江新香 唐国瑶 LU Chenghui;YANG Chenglong;ZHOU Xuan;JIANG Xinxiang;TANG Guoyao(Department of Stomatology,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine/Core Unit of National Clinical Research Center for Oral Diseases,Shanghai 200092,China;Department of Rehabilitation Medicine,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Department of Oral Mucosal Diseases,The Affiliated Stomatology Hospital of Guilin Medical University,Guilin 541004,China)

机构地区：[1]上海交通大学医学院附属新华医院口腔科,国家口腔疾病临床医学研究中心核心单位,上海200092 [2]上海交通大学医学院附属新华医院康复医学科,上海200092 [3]桂林医学院附属口腔医院口腔黏膜病科,广西桂林541001

出　　处：《口腔疾病防治》2025年第5期377-384,共8页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：上海卫健委临床科研资助项目(202040458);上海交通大学医学院附属新华医院“学科攀峰计划”建设项目(XKPF2024B500)。

摘　　要：目的探讨灼口综合征(burning mouth syndrome,BMS)患者睡眠质量状况及其影响因素,为制定改善BMS患者的睡眠干预措施提供依据。方法本研究已通过单位医学伦理委员会审查批准,并获得患者知情同意。本研究选取150例BMS患者作为研究对象,同时纳入150例健康对照者,使用匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)评估睡眠质量,使用视觉模拟评分法(visual analog scale,VAS)评估口腔黏膜疼痛程度,广泛性焦虑量表(generalized anxiety disorder 7-item scale,GAD-7)评估焦虑症状的发生频率,患者健康问卷抑郁量表(patient health questionnaire-9,PHQ-9)评估抑郁症状的发生频率。采用单因素分析方法筛选影响BMS患者睡眠质量的潜在因素,并运用多元线性回归模型分析其独立危险因素。结果BMS患者的PSQI评分为(7.61±4.29)分,高于健康对照者,差异具有统计学意义(P=0.016)。在PSQI的子量表评分方面,BMS患者相较于健康对照者,入睡时间延长、睡眠时间减少、睡眠效率降低(P<0.05)。伴有睡眠困难的BMS患者的GAD-7和PHQ-9评分高于无睡眠困难的BMS患者(P<0.001),但疼痛VAS评分两者无显著差异(P=0.068)。多元线性回归分析结果显示,病程长(>6个月)、伴随其他全身症状(头痛、精神压力大)以及抑郁症状评分高可能是影响BMS患者睡眠质量的独立风险因素。结论对于BMS患者,病程长、存在头痛、精神压力大、抑郁症状可能是其睡眠质量的独立影响因素。Objective To investigate the sleep quality in patients with burning mouth syndrome(BMS)and its influencing factors,providing a basis for developing sleep intervention measures to reduce the impact of BMS symptoms.Methods This study was reviewed and approved by the Medical Ethics Committee,and informed consent was obtained from patients.A total of 150 patients with BMS and 150 healthy volunteers were enrolled as subjects in this study.The Pittsburgh sleep quality index(PSQI)was used to assess the sleep quality of patients with BMS.Visual analog scale(VAS)was used to assess the degree of oral mucosal pain,generalized anxiety disorder 7-item scale(GAD-7)was used to assess the frequency of anxiety symptoms,and the patient health questionnaire depression questionnaire(PHQ-9)was used to assess the frequency of depression symptoms.Univariate analysis was performed to identify potential influencing factors affecting sleep quality in patients with BMS,and multiple linear regression analysis was employed to determine independent risk factors.Results The PSQI score for patients with BMS was 7.61±4.29,which was significantly higher than that of healthy controls(P=0.016).In the PSQI subscale analysis,patients with BMS exhibited increased sleep latency,decreased sleep duration,and lower sleep efficiency compared to healthy controls(P<0.05).Patients with BMS and comorbid sleep difficulties had significantly higher scores on GAD-7 and PHQ-9 compared to the patients with BMS without sleep difficulties(P<0.001),but there was no significant difference in pain VAS scores between the two(P=0.068).Multiple linear regression analysis revealed that longer disease duration(>6 months),the presence of systemic concomitant symptoms(such as headache and mental stress),and higher depression scores were identified as independent risk factors affecting sleep quality in patients with BMS.Conclusion For patients with BMS,long course of illness,presence of headaches,high mental stress,and depressive symptoms may be independent factors affecting t

关 键 词：灼口综合征 睡眠质量 睡眠困难 烧灼感 负性情绪 焦虑症状 抑郁症状 影响因素 

分 类 号：R78[医药卫生—口腔医学]