文拉法辛联合酸枣仁汤加味治疗抑郁伴失眠的疗效观察  

Observation on the curative effect of Venlafaxine combined with Modified Suanzaoren Decoction in the treatment of depression with insomnia

作　　者：张广平 晏海飞 饶娟 蔡三江 桂永平 王平 ZHANG Guangping;YAN Haifei;RAO Juan;CAI Sanjiang;GUI Yongping;WANG Ping(Department of Psychiatry,North Hospital of Xinyu Traditional Chinese Medicine Hospital,Jiangxi Province,Xinyu 338000,China)

机构地区：[1]江西省新余市中医院北院精神科,江西新余338000

出　　处：《中国当代医药》2025年第9期108-111,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0335)。

摘　　要：目的探讨文拉法辛联合酸枣仁汤加味治疗抑郁伴失眠的效果。方法选取2023年9月至2024年4月新余市中医院北院收治的60例抑郁症伴失眠患者作为研究对象,按照随机数字表法分为观察组(30例)与对照组(30例)。对照组采用文拉法辛治疗,观察组采用文拉法辛联合酸枣仁汤加味治疗。比较两组的治疗效果、药物副反应量表(TESS)评分以及治疗前后抑郁自评量表(SDS)评分、汉密尔顿抑郁量表(HAMD)评分、匹兹堡睡眠质量指数(PSQI)评分、36条简明健康状况调查表(SF-36)评分。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后的SDS评分、HAMD评分均低于对照组,差异有统计学意义(P<0.05);观察组治疗后的PSQI评分低于对照组,SF-36评分高于对照组,差异有统计学意义(P<0.05);两组的TESS评分比较,差异无统计学意义(P>0.05)。结论文拉法辛联合酸枣仁汤加味治疗抑郁伴失眠疗效显著,能够有效改善患者的抑郁症状、睡眠质量和生活质量,且安全性较好,值得临床应用。Objective To explore the effect of Venlafaxine combined with Modified Suanzaoren Decoction on depression with insomnia.Methods Sixty patients with depression and insomnia admitted to the North Hospital of Xinyu Hospital of Traditional Chinese Medicine Hospital from September 2023 to April 2024 were selected as the research objects,and they were divided into observation group(30 cases)and control group(30 cases)according to random number table method.The control group was treated with Venlafaxine,while the observation group was treated with Venlafaxine combined with Modified Suanzaoren Decoction.The treatment effect,treatment emergent symptom scale(TESS)score and self-rating depression scale(SDS)score,Hamilton depression scale(HAMD)score,Pittsburgh sleep quality index(PSQI)score and the MOS 36-item short-form health survey(SF-36)score before and after treatment were compared between the two groups.Results The total effective rate of observation group was higher than that of control group,the difference was statistically significant(P<0.05).The SDS and HAMD scores of observation group were lower than those of control group after treat-ment,the differences were statistically significant(P<0.05).The PSQI score of the observation group was lower than that of the control group,and the SF-36 score was higher than that of the control group after treatment,the differences were statistically significants(P<0.05).There was no significant difference in TESS scores between the two groups(P>0.05).Conclusion Venlafaxine combined with Modified Suanzaoren Decoction is effective in the treatment of depression accompa-nied by insomnia,which can effectively improve the depressive symptoms,sleep quality and quality of life of patients,and has good safety,which is worthy of clinical application.

关 键 词：抑郁 失眠 文拉法辛 酸枣仁汤加味 

分 类 号：R749[医药卫生—神经病学与精神病学]