淋巴瘤患者自体造血干细胞采集成功率的影响因素分析  

Analysis of the influencing factors of the success rate of autologous hematopoietic stem cell collection in lymphoma patients

作　　者：彭思祎 李敏燕 刘景华 刘洋 张美玉 佟丹江 赵婕 王吉刚 Peng Siyi;Li Minyan;Liu Jinghua;Liu Yang;Zhang Meiyu;Tong Danjiang;Zhao Jie;Wang Jigang(Department of Hematology,General Hospital of Northern Theater Command,Shenyang 110016,China)

机构地区：[1]北部战区总医院血液内科,沈阳110016

出　　处：《中国临床实用医学》2025年第1期13-18,共6页China Clinical Practical Medicine

基　　金：辽宁省科学技术计划项目(2021JH2/10300119)。

摘　　要：目的分析淋巴瘤患者自体造血干细胞采集成功率的相关影响因素。方法本研究为回顾性病例对照研究,选取2020年8月至2024年8月于北部战区总医院血液内科行自体造血干细胞采集的45例淋巴瘤患者,男26例,女19例,年龄45.0(36.5,58.0)岁,年龄范围为20~69岁。比较患者性别、年龄、2014版Lugano分期、动员前化学治疗周期、结外病变情况、复发情况、动员前疾病状态、国际预后指数(IPI)评分,采用单因素及二元logistic回归分析筛选影响淋巴瘤患者自体造血干细胞采集成功率的危险因素。结果首日采集(采集第1日)获得CD34+造血干细胞为[3.03(0.04,30.30)]×10^(6)/kg,其中31例患者首日采集成功,14例患者首日采集失败,需进行第2日采集。采集完成后获得CD34+造血干细胞为[3.45(0.09,55.20)]×10^(6)/kg,其中37例患者采集成功,8例患者采集失败。采集成功患者与采集失败患者的性别、2014版Lugano分期、结外病变情况、复发情况、IPI评分比较,差异无统计学意义(P>0.05);采集成功患者的年龄、动员前化学治疗周期、动员前疾病状态与采集失败患者比较,差异有统计学意义(P<0.05)。二元logistic回归分析结果表明,动员前疾病状态≤部分缓解是自体造血干细胞采集的危险因素(OR=0.189,95%CI:0.031~1.153,P=0.034)。结论年龄、动员前化学治疗周期次数、动员前疾病状态与自体造血干细胞采集成功率有关,其中动员前疾病状态≤部分缓解是影响自体造血干细胞采集效果的独立危险因素。ObjectiveAnalyze the related influencing factors of the success rate of autologous hematopoietic stem cell collection in lymphoma patients.MethodsThis study was a retrospective case-control study,which included 45 lymphoma patients who underwent autologous hematopoietic stem cell collection in department of Hematology at the General Hospital of Northern Theater Command from August 2020 to August 2024,including 26 males 19 females,aged 45.0(36.5,58.0)years old,the age ranging from 20 to 69 years old.The gender,age,Lugano staging with 2014 edition,the number of pre-mobilization chemotherapy cycles,presence of extranodal lesions,relapse status,pre-mobilization disease condition,and international prognostic index(IPI)score of the patients were compared,and the risk factors affecting the success rate of autologous hematopoietic stem cell collection in lymphoma patients were screened by using univariate and multivariate logistic regression analysis.ResultsThe CD34+hematopoietic stem cells collected on the first day was[3.03(0.04,30.30)]×10^(6)/kg,collection was successful in 31 patients,while 14 patients did not reach the target and required a second day of collection.By the end of the collection process,the CD34+cells obtained was[3.45(0.09,55.20)]×10^(6)/kg,with 37 patients successfully reaching the target and 8 patients failing to do so.Comparing the successful and unsuccessful collection groups,there were no significant differences in gender,Lugano staging with 2014 edition,presence of extranodal lesions,relapse status and IPI score(P>0.05).The age,the number of pre-mobilization chemotherapy cycles,pre-mobilization disease condition showed significant differences between the successful and unsuccessful collection groups(P<0.05).The results of multivariate logistic regression analysis showed that pre-mobilization disease condition≤partial remission was a risk factor for autologous hematopoietic stem cell collection(OR=0.189,95%CI:0.031 to 1.153,P=0.034).ConclusionsAge,number of pre-mobilization chemotherapy cycl

关 键 词：淋巴瘤 造血干细胞采集 自体造血干细胞移植 自体造血干细胞 

分 类 号：R733.1[医药卫生—肿瘤]