尿激酶静脉溶栓与rt-PA静脉溶栓治疗急性脑梗死的疗效对比研究  

Comparative study on the efficacy of intravenous thrombolysis with urokinase and intravenous thrombolysis with rt-PA in the treatment of acute cerebral infarction

作　　者：靳辉 朱晓俊 陈层 王璇 JIN Hui;ZHU Xiaojun;CHEN Ceng;WANG Xuan(Department of Neurology,Midong District People's Hospital,Urumqi,Urumqi,Xinjiang 831400,China)

机构地区：[1]乌鲁木齐市米东区人民医院神经内科,新疆乌鲁木齐831400

出　　处：《医药前沿》2025年第12期33-35,共3页Journal of Frontiers of Medicine

基　　金：乌鲁木齐市卫生健康委科技计划项目(202048)。

摘　　要：目的对比重组组织型纤溶酶原激活剂(rt-PA)和尿激酶(UK)静脉溶栓治疗急性脑梗死的疗效。方法选取2019年6月—2023年11月乌鲁木齐市米东区人民医院收治的80例急性脑梗死患者,根据随机数字表法分为两组各40例。rt-PA组采用rt-PA静脉溶栓治疗,UK组采用UK静脉溶栓治疗。比较两组神经功能缺损评分、日常生活能力评分以及改良Rankin量表(mRS)评分。结果溶栓前及溶栓后1、7 d,两组神经功能缺损评分、神经功能缺损评分下降≥4分的患者占比、日常生活能力评分、日常生活能力评分≥70分的患者占比比较,差异无统计学意义(P>0.05);两组溶栓后7、14 d mRS评分及溶栓后14 dmRS≤2分的患者占比比较,差异无统计意义(P>0.05)。结论在急性脑梗死患者发病4.5 h内,rt-PA静脉溶栓和UK静脉溶栓的治疗效果相当,但UK治疗费用更低,时间窗更长,患者更容易接受,值得在基层医院和贫困地区临床工作中推广。Objective To compare the efficacy of recombinant tissue plasminogen activator(rt-PA)and urokinase(UK)intravenous thrombolysis for acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction admitted to the Midong District People's Hospital,Urumqi from June 2019 to November 2023 were selected,according to the random number table method,they were randomly divided into two groups,with 40 cases in each group.rt-PA group was treated with rt-PA intravenous thrombolysis,urokinase group was treated with UK intravenous thrombolysis.The neurological deficit score,ability of daily living score and Modified Rankin Scale(mRS)score of the two groups were compared.Results There was no significant difference in neurological deficit score,the proportion of patients with neurological deficit score decreased by≥4 points,the ability of daily living score,the proportion of patients with ability of daily living score≥70 points between the two groups before thrombolysis,1 and 7 days after thrombolysis(P>0.05);there was no significant difference in mRS score at 7 and 14 days after thrombolysis and the proportion of patients with mRS≤2 at 14 days after thrombolysis between the two groups(P>0.05).Conclusions Within 4.5 hours of the onset of acute cerebral infarction,the therapeutic effects of rt-PA intravenous thrombolysis and UK intravenous thrombolysis are comparable,but the cost used in UK treatment is lower,the time window is longer,and patients are more likely to accept it,which is more worthwhile to be popularized in grassroots hospitals and the clinical work of the poor areas.

关 键 词：重组组织型纤溶酶原激活剂 尿激酶 急性脑梗死 静脉溶栓 神经功能缺损 日常生活能力 

分 类 号：R743[医药卫生—神经病学与精神病学]