甘草泻心汤联合复方氯己定含漱液治疗复发性口腔溃疡寒热错杂证的临床研究  

Clinical observation of Gancao Xiexin Decoction combined with compound chlorhexidine gargle in the treatment of recurrent oral ulcer

作　　者：王海舰 徐耀[2] 王金星 李奇阳 张亚男 马桂琴[4] WANG Hai-jian;XU Yao;WANG Jin-xing;LI QI-yang;ZHANG Ya-nan;MA Gui-qin

机构地区：[1]北京市化工职业病防治院(北京市职业病防治研究院),北京100093 [2]航天中心医院,北京100049 [3]北京市石景山区中医医院,北京100043 [4]中国中医科学院广安门医院,北京100053

出　　处：《中国疗养医学》2025年第4期48-51,共4页Chinese Journal of Convalescent Medicine

基　　金：北京市中医管理局第三期仲景书院“仲景国医传人”精英班研修项目(京中医科字[2016]114号);北京市石景山区名中医传承工作室建设项目(石卫健中医发[2020]5号)。

摘　　要：目的 观察甘草泻心汤联合复方氯己定含漱液治疗复发性口腔溃疡(recurrent oral ulcer,ROU)寒热错杂证的临床效果。方法 筛选2022年1月至2024年7月在北京市化工职业病防治院中医门诊及航天中心医院中医门诊就诊的72例ROU寒热错杂证患者,按照随机数字表随机分为观察组和对照组,每组36例。对照组给予复方氯己定含漱液治疗,观察组在对照组基础上联合甘草泻心汤汤剂口服,连续用药1周。比较治疗前后两组疼痛视觉模拟量表(VAS)评分、症状体征积分(从溃疡面大小、渗出、充血、水肿、溃疡疼痛、烧灼感、口干口渴、便干便秘等综合判定),通过治疗前后症状体征积分评价治疗后的临床效果,3个月后电话随访复发情况。结果 治疗1周后观察组VAS评分、症状体征积分均低于对照组(P<0.05)。经Mann-Whitney U检验发现,观察组总有效率97.2%高于对照组总有效率94.4%,差异有统计学意义(P<0.001)。3个月后电话随访复发率,观察组复发率17.1%低于对照组复发率44.1%,经卡方检验,差异有统计学意义(P=0.015)。结论 甘草泻心汤联合复方氯己定含漱液治疗ROU寒热错杂证临床效果较好,在改善症状体征方面尤为明显,且能够降低复发率。Objective To observe the clinical efficacy of Gancao Xiexin Decoction combined with compound chlorhexidine gargle in the treatment of recurrent oral ulcer(ROU)with the intermingled cold and heat syndrome.Methods Seventy-two ROU patients with the intermingled cold and heat syndrome who visited the traditional Chinese medicine clinic of Beijing Chemical Occupational Disease Prevention and Control Institute and Aerospace Center Hospital from January 2022 to July 2024 were screened.They were randomly divided into the observation group and the control group using the random number table,with 36 cases in each group.Patients in the control group were treated with compound chlorhexidine gargle,and those in the observation group were orally administered Gancao Xiexin Decoction combined with compound chlorhexidine gargle.The medication was continued for 1 week.The visual analogue scale(VAS)score of the pain and the integral of symptoms and signs(comprehensively determined from the size of the ulcer surface,exudation,congestion,edema,ulcer pain,burning sensation,dry mouth and thirst,dry stool and constipation,etc.)before and after treatment in both groups were compared.The clinical effect after the treatment was evaluated through the integral of symptoms and signs before and after treatment,and the recurrence situation was followed up by telephone contact 3 months later.Results After 1 week of treatment,the VAS score and the integral of symptoms and signs in the observation group were significantly lower than those of the control group(P<0.05).Through the Mann-Whitney U test,the total effective rate of the observation group was significantly higher than that of the control group(97.2%VS 94.4%,P<0.001).The recurrence rate was followed up by telephone 3 months later.Through the chi-square test,the recurrence rate of the observation group was significantly lower than that of the control group(17.1%VS 44.1%,P=0.015).Conclusion Gancao Xiexin Decoction combined with compound chlorhexidine gargle has a better effect on the treatme

关 键 词：复发性口腔溃疡 甘草泻心汤 复方氯己定含漱液 疗效 

分 类 号：R781.5[医药卫生—口腔医学]