基于“原络配穴”针刺联合艾灸治疗脑梗死相关失眠的疗效及对血清下丘脑泌素-1、5羟色胺和脑电慢波的影响  

The therapeutic effect of acupuncture combined with moxibustion on insomnia related to cerebral infarc-tion based on the"Yuan-Luo Point Pairing"and its impact on serum Hcrt-1,5-HT,and slow wave EEG

作　　者：杨涵棋 何玲娜[1] YANG Hanqi;HE Lingna(Department of Acupuncture,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China)

机构地区：[1]成都中医药大学附属医院针灸科,四川成都610075

出　　处：《实用医学杂志》2025年第8期1253-1258,共6页The Journal of Practical Medicine

基　　金：四川省中医药管理局科学技术研究专项项目(编号:2020LC0086)。

摘　　要：目的探讨基于“原络配穴”针刺联合艾灸治疗脑梗死相关失眠的疗效及对血清下丘脑泌素-1(Hcrt-1)、5羟色胺(5-HT)及脑电慢波的影响。方法选取2022年7月至2024年7月医院收治的120例脑梗死相关失眠患者为研究对象,以随机数字表法分为观察组、对照组,各60例。对照组以常规西药治疗,观察组在对照组基础上增加基于“原络配穴”针刺联合艾灸治疗。比较两组临床疗效、中医证候积分、睡眠质量、血清Hcrt-1和5-HT、脑电慢波指标、治疗安全性。结果观察组总有效率高于对照组(P<0.05)。观察组中医证候积分胆怯易惊、心悸不宁、气短懒言、面色无华均低于对照组(P<0.05)。治疗后,观察组睡眠质量指标包括入睡潜伏期、快速眼动睡眠期低于对照组,睡眠总时间、睡眠效率高于对照组(P<0.05)。治疗后,观察组血清Hcrt-1、5-HT均低于对照组(P<0.05)。治疗后,观察组脑电慢波包括θ波、δ波频率小于对照组,波幅大于对照组(P<0.05)。两组不良反应发生率无差异性(P>0.05)。结论基于“原络配穴”针刺联合艾灸治疗脑梗死相关失眠的疗效显著,可降低患者中医证候,提高患者睡眠质量,降低血清Hcrt-1、5-HT水平,改善患者脑电慢波状态,治疗安全性良好。Objective To investigate the efficacy of acupuncture combined with moxibustion based on"Yuan⁃Luo Point Pairing"in treating insomnia related to cerebral infarction,and its effects on serum hypotha⁃lamic secretin-1(Hcrt-1),5-hydroxytryptamine(5-HT),and slow wave EEG.Methods 120 patients with cerebral infarction related insomnia admitted to our hospital from July 2022 to July 2024 were selected as the research subjects.They were randomly divided into an observation group and a control group,with 60 cases in each group,using a random number table method.The control group was treated with routine western medicine,and the observation group was treated with acupuncture combined with moxibustion based on"Yuan⁃Luo Point Pairing"on the basis of the control group.Compared the clinical efficacy,TCM syndrome score,sleep quality,serum Hcrt-1 and 5-HT,EEG slow wave indicators,and treatment safety of two groups.Results The effective rate of observa⁃tion group was higher than control group(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of observation group were lower than control group(P<0.05),including timidity,palpitations,shortness of breath,lazy speech,and no complexion.After treatment,the sleep quality indicators of the observation group,including sleep latency and rapid eye movement sleep were lower than those of the control group,while the total sleep time and sleep efficiency were higher than group control(P<0.05).After treatment,the serum Hcrt-1 and 5-HT levels of observation group were lower than group control(P<0.05).the slow waves in EEG,includingθandδwaves of observation group had lower frequencies than the control group and higher amplitudes than control group(P<0.05).Conclusions Acupuncture combined with moxibustion based on"Yuan⁃Luo Point Pairing"has significant therapeutic effects on insomnia related to cerebral infarction.It can reduce traditional Chinese medicine syndromes,improve sleep quality,lower serum Hcrt-1 and 5-HT levels,improve slow wave state of EEG in patients,an

关 键 词：脑梗死相关失眠 原络配穴 针刺 艾灸 临床疗效 血清下丘脑泌素-1 5羟色胺 脑电慢波 

分 类 号：R743[医药卫生—神经病学与精神病学] R256.23[医药卫生—临床医学]