微囊样黄斑水肿在青光眼中的研究进展  

Research progress on microcystic macular edema in glaucoma:current status

作　　者：刘媛 左成果 刘杏[1] Liu Yuan;Zuo Chengguo;Liu Xing(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology Visual Science,Guangzhou 510060,China)

机构地区：[1]中山大学中山眼科中心眼病防治全国重点实验室、广东省眼科视觉科学重点实验室,广州510060

出　　处：《中华眼底病杂志》2025年第4期307-310,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金(81970808、82271080)。

摘　　要：微囊样黄斑水肿(MME)是可见于青光眼患者视网膜内核层的一种病理改变,常见于中晚期青光眼患者,研究多集中在原发性开角型青光眼。研究表明,MME的发生与年轻患者、青光眼严重程度及病程进展有关,发生于旁中心凹区域,常见于下半部分的视网膜区域,与青光眼易损区域相对应。MME可能影响光相干断层扫描检查图像的自动分层,这提示临床医生应当注重MME的发生,以免对疾病病情产生误判。目前认为MME在青光眼中的发生可能与黄斑玻璃体牵引、支架机械应力、Müller细胞功能障碍有关。深入研究MME在青光眼中的具体病理生理机制,将有助于为青光眼的诊断、病情监测及治疗效果评估提供新的视角和科学依据。Microcystic macular edema(MME)represents a pathological change that can be observed in the inner layer of the retina in patients diagnosed with glaucoma.This phenomenon is particularly prevalent in individuals with moderate to advanced glaucoma.The majority of research in this field has focused on primary open-angle glaucoma.The occurrence of MME in glaucoma has been demonstrated to be associated with younger age,advanced stage and disease progression.MME occurs in the parafoveal region,most frequently located in the inferior perimacular region,which corresponded with the most vulnerable area of ganglion cells in glaucoma.The presence of MME may affect the automatic layering of optical coherence tomography images,suggesting that clinicians should be mindful of the occurrence of MME to avoid misdiagnosis of the disease.It is hypothesised that the occurrence of MME in glaucoma may be related to macular vitreous traction,mechanical stress of the stent,and Müller cell dysfunction.A comprehensive investigation of the precise pathophysiological mechanism of MME in glaucoma will facilitate the development of a novel perspective and a scientific foundation for the diagnosis,disease monitoring and evaluation of treatment efficacy in glaucoma.

关 键 词：青光眼 微囊样黄斑水肿 光相干断层扫描 综述 

分 类 号：R775[医药卫生—眼科]