人羊膜在眼底疾病中应用的研究进展  

Research progress on the application of human amniotic membrane in ocular fundus diseases

作　　者：朱方兴 刘建东 高荣玉 任建涛 孙学泉 黄旭东 Zhu Fangxing;Liu Jiandong;Gao Rongyu;Ren Jiantao;Sun Xuequan;Huang Xudong(School of Clinical Medicine,Shandong Second Medical University,Weifang 261041,China;Zhengda Guangming Eye Group,Weifang Eye Hospital,Weifang Eye Institute,Weifang 261041,China)

机构地区：[1]山东第二医科大学临床医学院山东第二医科大学,潍坊261041 [2]正大光明眼科集团潍坊眼科医院潍坊市眼科研究所,潍坊261041

出　　处：《中华眼底病杂志》2025年第4期324-328,共5页Chinese Journal of Ocular Fundus Diseases

摘　　要：人羊膜(hAM)作为一种生物材料,在眼科领域中的应用已取得显著进展,特别是在眼底疾病的治疗上。hAM具有促进组织修复、抑制炎症和新生血管生长、减少纤维化等生物学特性,使其在治疗黄斑裂孔、视网膜脱离、增生性玻璃体视网膜病变、视盘凹陷相关黄斑脱离以及年龄相关性黄斑变性等疾病中显示出良好的临床效果。hAM的应用能够提高手术成功率,促进视力恢复,且由于其低免疫原性,未观察到明显的排斥反应。尽管如此,hAM的应用仍面临制备与保存技术的优化、治疗效能的提升以及降低传染性疾病传播风险的挑战。未来的研究需致力于解决这些问题,以进一步推广hAM在眼底疾病治疗中的应用,并提高治疗的有效性。Human amnion(hAM),as a biomaterial,has made significant progress in the field of ophthalmology,particularly in the treatment of retinal diseases.hAM possesses biological properties such as promoting tissue repair,inhibiting inflammation and neovascularization,and reducing fibrosis,which have led to its promising clinical outcomes in treating macular holes,retinal detachment,proliferative vitreoretinopathy,optic disc depression-related macular detachment,and age-related macular degeneration.The application of hAM can improve surgical success rates and promote vision recovery,with no significant rejection reactions observed due to its low immunogenicity.Nevertheless,the use of hAM still faces challenges in optimizing preparation and storage techniques,enhancing therapeutic efficacy,and reducing the risk of infectious disease transmission.Future research should focus on addressing these issues to further promote the application of hAM in retinal disease treatment and enhance its effectiveness.

关 键 词：羊膜 黄斑裂孔 孔源性视网膜脱离 年龄相关性黄斑变性 综述 

分 类 号：R77[医药卫生—眼科]