桧烯微胶囊制备工艺研究  

Study on Preparation Technology of Sabinene Microcapsules

作　　者：杨丽 赵威 唐双庆 赵鑫 魏琴[1] YANG Li;ZHAO Wei;TANG Shuangqing;ZHAO Xin;WEI Qin(Sichuan Youzhang Engineering Technology Research Center,Yibin University,Yibin 644000,China)

机构地区：[1]宜宾学院四川省油樟工程技术研究中心,四川宜宾644000

出　　处：《林产化学与工业》2025年第2期10-18,共9页Chemistry and Industry of Forest Products

基　　金：四川省科技计划项目(21MZGC0220)。

摘　　要：为掩蔽桧烯的刺鼻气味,同时提高其在工业原料中的分散度,降低挥发率,以桧烯为芯材,β-环糊精为壁材,无水乙醇作桧烯溶剂,采用真空干燥法制备桧烯微胶囊。以包合产率和包合率的综合评分为评价指标,通过单因素试验和响应面试验对桧烯微胶囊的制备工艺进行优化,桧烯微胶囊制备的最佳工艺条件为:壁材和芯材比例(壁芯比)9.6∶1(g∶mL),包合温度42℃,包合时间3.2 h,水与壁材比例(水壁比)12∶1(mL∶g),无水乙醇和芯材体积比(醇芯比)5∶1。在该制备工艺下,桧烯微胶囊的包合率为78.38%±1.76%,包合产率为72.40%±0.58%,综合得分为(77.18±1.53)分,与响应面模型预测值相差较小,该模型预测结果可靠。桧烯微胶囊在扫描电镜(SEM)下形态呈现块絮状,包合效果良好。桧烯微胶囊的挥发率为(2.28±0.08)%/h远低于桧烯本身的挥发率(4.87±0.06)%/h,说明桧烯微胶囊化可以对桧烯起到缓释作用。In order to mask the pungent smell of sabinene,and improve its dispersion in industrial raw materials,reduce the volatilization rate,with sabinene as the core material,β-cyclodextrin as the wall material,a sabinene microcapsule was prepared by vacuum drying method.Taking the comprehensive scores of cladding yield and cladding rate as evaluation indexes,the preparation process of sabinene microcapsules was optimized by univariate test and response surface test.The results showed that the optimum preparation conditions of sabinene microcapsules were as follows:wall-core ratio of 9.6∶1(g∶mL),wrapping temperature of 42℃,wrapping time of 3.2 h,water-wall ratio of 12∶1(mL∶g),alcohol-core ratio of 5∶1.Under this preparation condition,the cladding rate of sabinene microcapsules was 78.38%±1.76%,the cladding yield was 72.40%±0.58%,and the comprehensive score was(77.18±1.53)points,which was little different from the predicted value of the response surface model,and the prediction results of the model were reliable.Sabinene-loaded microcapsules were observed by scanning electron microscopy(SEM),exhibiting flocculent cluster morphology,which demonstrated effective encapsulation.The volatilization rate of sabinene microcapsules was(2.28%±0.08%)/h,which was much lower than that of sabinene itself(4.87%±0.06%)/h,indicating that microencapsulation of sabinene could play a slow-release effect on sabinene.

关 键 词：桧烯 微胶囊 制备工艺 响应面 

分 类 号：TQ35[化学工程]