人乳头瘤病毒阳性宫颈癌组织TRIM3、TRIM44与临床病理参数和预后的关系  

Relationship between TRIM3 and TRIM44 and clinicopathological parameters and prognosis in human papillomavirus positive cervical cancer tissues*

作　　者：袁魁 宋明 那彩凤 洪彻 刘博宇 YUAN Kui;SONG Ming;NA Caifeng;HONG Che;LIU Boyu(Department of Gynecology and Oncology,Mudanjiang Tumor Hospital,Mudanjiang,Heilongjiang 157000,China)

机构地区：[1]牡丹江市肿瘤医院妇瘤科,黑龙江牡丹江157000

出　　处：《国际检验医学杂志》2025年第8期910-914,920,共6页International Journal of Laboratory Medicine

基　　金：黑龙江省卫生厅科研课题(2019-076)。

摘　　要：目的探讨人乳头瘤病毒(HPV)阳性宫颈癌组织三基序蛋白(TRIM)3、TRIM44与临床病理参数和预后的关系。方法收集该院2019年2月至2021年2月收治的158例HPV阳性宫颈癌患者癌组织及癌旁正常宫颈组织(距癌灶切缘≥2 cm),另收集该院同期收治的100例HPV阴性宫颈癌患者的癌组织。采用免疫组织化学法检测并比较HPV阳性宫颈癌患者癌组织及其癌旁正常宫颈组织、HPV阴性宫颈癌患者癌组织中TRIM3、TRIM44阳性表达率。分析TRIM3、TRIM44阳性表达率与HPV阳性宫颈癌患者临床病理参数的关系。采用Kaplan-Meier生存曲线分析TRIM3表达阴性和阳性、TRIM44表达阴性和阳性患者的3年累积生存率。采用COX回归模型分析HPV阳性宫颈癌患者预后的影响因素。结果与癌旁正常宫颈组织及HPV阴性宫颈癌组织比较,HPV阳性宫颈癌组织中TRIM3阳性表达率降低(P<0.05),TRIM44阳性表达率升高(P<0.05)。相较于FIGO分期ⅠA~ⅠB期、无淋巴结转移者,FIGO分期ⅡA期、有淋巴结转移者的TRIM3阳性表达率降低明显(P<0.05),而TRIM44阳性表达率升高明显(P<0.05)。158例HPV阳性宫颈癌患者随访3年期间失访3例,最终获得随访155例。Kplan-Meier生存曲线结果显示,TRIM3阴性表达组3年累积生存率明显低于TRIM3阳性表达组(P<0.05);TRIM44阳性表达组3年累积生存率明显低于TRIM44阴性表达组(P<0.05)。COX回归分析显示,淋巴结转移、FIGO分期ⅡA期、TRIM3阴性表达、TRIM44阳性表达是HPV阳性宫颈癌患者预后的危险因素(P<0.05)。结论HPV阳性宫颈癌组织中TRIM3呈低表达,TRIM44呈高表达,二者表达与淋巴结转移、FIGO分期及3年累积生存率降低有关。Objective To investigate the relationship between triple motif protein(TRIM)3,TRIM44 and clinicopathological parameters and prognosis in human papillomavirus(HPV)positive cervical cancer tissues.Methods The cancer tissues and adjacent normal cervical tissues(≥2 cm from the resection margin of the cancer)of 158 patients with HPV positive cervical cancer admitted to the hospital from February 2019 to February 2021 were selected,and the cancer tissues of 100 patients with HPV negative cervical cancer admitted to the hospital during the same period were selected.The positive expression rates of TRIM3 and TRIM44 in cancer tissues of HPV positive cervical cancer patients and their adjacent normal cervical tissues,and cancer tissues of HPV negative cervical cancer patients were detected and compared by immunohistochemistry.The relationship between the positive expression rate of TRIM3 and TRIM44 and the clinicopathological parameters of HPV positive cervical cancer patients was analyzed.The 3-year cumulative survival rate of patients with negative/positive TRIM3 expression and negative/positive TRIM44 expression were analyzed by Kaplan-Meier survival curve.The influencing factors of the prognosis of HPV positive cervical cancer patients were analyzed by COX regression model.Results Compared with adjacent normal cervical tissues and HPV negative cervical cancer tissues,the positive expression rate of TRIM3 in HPV positive cervical cancer tissues was significantly decreased(P<0.05),and the patients expression rate of TRIM44 was significantly increased(P<0.05).Compared with the patients with FIGO stageⅠA-ⅠB and no lymph node metastasis,the patients with FIGO stageⅡA and lymph node metastasis,the positive rate of TRIM3 expression decreased significantly(P<0.05),while the positive rate of TRIM44 expression increased significantly(P<0.05).A total of 3 patients were lost during the 3-year follow-up among 158 HPV positive cervical cancer patients,and 155 patients were finally followed up.Kplan-Meier survival curve showe

关 键 词：人乳头瘤病毒阳性 宫颈癌 三基序蛋白3 三基序蛋白44 预后 

分 类 号：R737.3[医药卫生—肿瘤]