血清甲胎蛋白异质体3和β2微球蛋白异常表达预测肝癌患者介入治疗术后并发症的价值  

Value of abnormal expression of serum alpha fetoprotein variant 3 andβ_(2)microglobulin in predicting complications after interventional surgery in patients with liver cancer

作　　者：马亮亮 黄凯[1] 李丽[1] 任东晓 高树建 董深明 MA Liangliang;HUANG Kai;LI Li;REN Dongxiao;GAO Shujian;DONG Shenming(Department of Tumor Intervention,Qilu Hospital of Shandong University Dezhou Hospital,Dezhou,Shandong 253000,China)

机构地区：[1]山东大学齐鲁医院德州医院肿瘤介入科,山东德州253000

出　　处：《国际检验医学杂志》2025年第8期921-925,共5页International Journal of Laboratory Medicine

基　　金：山东省重点研发计划(软科学项目)(2021RKC03001)。

摘　　要：目的分析血清甲胎蛋白异质体3(AFP-L3)和β_(2)微球蛋白(β_(2)-MG)异常表达预测肝癌患者介入治疗术后并发症的价值。方法回顾性收集2020年1月至2023年12月在该院进行介入治疗的92例肝癌患者的临床资料,根据患者介入治疗术后是否出现并发症分为并发症组(33例)和非并发症组(59例),分别检测两组AFP-L3及β_(2)-MG水平。采用多因素Logistic回归分析肝癌患者介入治疗术后并发症发生的影响因素,受试者工作特征(ROC)曲线评价AFP-L3及β_(2)-MG水平预测肝癌患者介入治疗术后并发症发生的价值。结果与非并发症组比较,并发症组有糖尿病史、乙型肝炎病毒(HBV)-DNA阳性、组织学低分化者占比及AFP-L3、β_(2)-MG水平更高(P<0.05),且肝癌病程更长(P<0.05)。多因素Logistic回归分析显示,AFP-L3和β_(2)-MG水平是肝癌患者介入治疗术后并发症发生的独立危险因素(P<0.05)。AFP-L3和β_(2)-MG水平预测肝癌患者介入治疗术后并发症发生的曲线下面积(AUC)分别为0.874、0.854,灵敏度分别为89.77%、74.79%,特异度分别为87.21%、84.82%,最佳截断值分别为92.28μg/L、4.43 mg/L。AFP-L3和β_(2)-MG水平联合预测术后并发症发生的AUC为0.910,要明显优于单项指标的预测价值(P<0.05)。结论血清高水平AFP-L3及β_(2)-MG可能是肝癌患者介入治疗术后并发症发生的独立危险因素,两项血清指标联合检测对于术后并发症发生有更高的预测价值,为临床评估肝癌患者介入治疗术后并发症提供了新的手段。Objective To analyze the value of abnormal expression of serum alpha fetoprotein variant 3(AFP-L3)andβ_(2)microglobulin(β_(2)-MG)in predicting complications after interventional surgery in patients with liver cancer.Methods Clinical information of totally 92 patients with liver cancer who underwent interventional surgery in the hospital from January 2020 to December 2023 were retrospectively collected and the patients were divided into complication group(33 cases)and non-complication group(59 cases)according to whether complications occurred after interventional surgery.The levels of AFP-L3 andβ_(2)-MG were detected respectively.Multivariate Logistic regression was used to analyze the the factors influencing the occurrence of complications in patients with liver cancer.Receiver operating characteristic(ROC)curve was used to evaluate the value of the levels of AFP-L3 andβ_(2)-MG to predict complications in patients with liver cancer.Results Compared with the non-complication group,the proportion of patients with a history of diabetes,positive hepatitis B virus(HBV)-DNA,poorly differentiated histology,and the levels of AFP-L3 andβ_(2)-MG were higher in the complication group(P<0.05),and the course of liver cancer was longer(P<0.05).Multivariate Logistic regression analysis showed that the levels of AFP-L3 andβ_(2)-MG were independent risk factors for complications after interventional surgery in patients with liver cancer.The area under the curve(AUC)of AFP-L3 andβ_(2)-MG levels in predicting complications after interventional surgery in patients with liver cancer were 0.874 and 0.854,respectively,with sensitivity of 89.77%and 74.79%,and specificity of 87.21%and 84.82%,respectively.The cut off values were 92.281μg/L and 4.430 mg/L,respectively.The AUC of the combination of AFP-L3 andβ_(2)-MG levels in predicting postoperative complications was 0.910,which was significantly better than the predictive value of the single indicator(P<0.05).Conclusion High levels of serum AFP-L3 andβ_(2)-MG may be independent

关 键 词：肝癌介入术 术后并发症 甲胎蛋白异质体3 β_(2)微球蛋白 预测价值 

分 类 号：R735.7[医药卫生—肿瘤]