以35岁为界不同年龄育龄期女性阴道微生态分析  

Comparison of vaginal microbiota between women of childbearing age stratified by the age of 35 years

作　　者：申亚倩 张敬 刘晓丹[1,2] 赵丽娟 颜军昊[1,2] SHEN Yaqian;ZHANG Jing;LIU Xiaodan;ZHAO Lijuan;YAN Junhao(Institute of Women,Children and Reproductive Health,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学妇儿与生殖健康研究院(山东大学附属生殖医院),山东济南250012 [2]山东大学生殖医学与子代健康全国重点实验室

出　　处：《精准医学杂志》2025年第2期166-169,共4页Journal of Precision Medicine

基　　金：山东省医药卫生科技发展计划项目(2018WS342)。

摘　　要：目的探讨以35岁为界不同年龄育龄期女性阴道微生态的差异,为育龄期女性的生殖健康提供指导。方法选取2016年1月—2018年12月于山东大学附属生殖医院常规体检且行阴道微生态检查的2683例育龄期女性作为研究对象,根据年龄分为<35岁组(A组)和35~49岁组(B组),分析两组研究对象的阴道微生态的差异。结果B组女性阴道微生态整体平衡比例、患细菌性阴道病(BV)者比例、优势菌群异常比例、pH值异常比例、清洁度异常比例、唾液酸苷酶异常比例、Nugent评分、白细胞酯酶异常比例、菌群多样性及菌群密集度与A组比较,差异均有显著性(Z=3.94,χ^(2)=5.70~29.43,P<0.05)。两组H_(2)O_(2)、乙酰氨基葡萄糖苷酶、脯氨酸氨基肽酶异常比例均无明显差异(P>0.05)。结论与<35岁的育龄期女性相比,≥35岁的育龄期女性阴道微生态异常比例升高,主要表现为BV患病比例升高,阴道内酸性环境受损,优势菌群异常比例升高。Objective To investigate the differences in vaginal microbiota between women of childbearing age stratified by the age of 35 years,and to provide guidance for the reproductive health of women.Methods A total of 2683 women of childbearing age who underwent routine physical examination and vaginal microbiota assessment in Center for Reproductive Medicine,Shandong University,from January 2016 to December 2018 were enrolled as subjects,and according to the age,they were all divided<35 years group(group A)and 35-49 years group(group B).The vaginal microbiota were compared between the two groups.[WTHX]Results There were significant differences between groups A and B in the proportion of women with balanced vaginal microbiota,bacterial vaginosis(BV),abnormal dominant bacteria,abnormal pH value,abnormal cleanliness,abnormal sialidase,abnormal Nugent scores,or leukocyte esterase abnormalities,as well as microbial diversity and density(Z=3.94,χ^(2)=5.70-29.43,P<0.05).There were no significant differences between the two groups in the proportion of women with abnormal H_(2)O_(2),N-acetylglucosaminidase,or proline aminopeptidase(P>0.05).Conclusion Compared with the women of childbearing age younger than 35 years,those aged≥35 years have a higher incidence rate of vaginal microbiota dysbiosis,mainly characterized by an increase in the prevalence rate of BV,impaired vaginal acidic environment,and an increase in the proportion of women with abnormal dominant bacteria.

关 键 词：生态失调 阴道病 细菌性 微生物群 阴道 女性 

分 类 号：R711.73[医药卫生—妇产科学]