生物反馈治疗仪在阿尔兹海默病患者的应用及对认知转归的影响  

Application of biofeedback instrument in patients with Alzheimer's disease and the effect of that on cognitive conversion

作　　者：许珉杰 陈开元 陈晓亚 李泽宇 苏晖[1] 严峰[1] Xu Minjie;Chen Kaiyuan;Chen Xiaoya;Li Zeyu;Su Hui;Yan Feng(ShangHai Mental Health Center,Shanghai 200030,China)

机构地区：[1]上海市精神卫生中心,上海200030

出　　处：《中国医学装备》2025年第4期90-94,共5页China Medical Equipment

基　　金：上海市科学技术委员会(18411952200)。

摘　　要：目的:观察生物反馈仪在阿尔兹海默病(AD)患者中的应用及对其认知转归的影响。方法:选取2022年2月至2024年2月上海市精神卫生中心收治的150例AD患者,按照随机数表法将其分为观察组和对照组,每组75例。对照组给予药物联合常规训练治疗,观察组在对照组治疗基础上应用生物反馈仪进行治疗,对比两组治疗效果和认知转归情况。结果:观察组治疗后依从率和家属对治疗结果的满意率分别为90.67%和94.67%,且高于对照组,数据缺失率为0,低于对照组,差异有统计学意义(x^(2)=15.213、6.313、8.451,P<0.05);两组各项指标与应用前相比均有改善,观察组脑电β波、SMR波水平,简易精神状态量表(MMSE)评分、蒙特尔认知评估(MoCA)评分均高于对照组,θ波水平和日常生活能力评估量表(ADL)评分低于对照组,差异有统计学意义(t=6.094、5.315、3.973、4.447、6.362、6.869,P<0.05);两组不良反应比较差异无统计学(P>0.05)。结论:生物反馈仪应用于AD患者,可促进认知转归,提高自理能力,安全性较高。Objective:To observe the application of biofeedback instrument in patients with Alzheimer’s disease(AD)and the effect of that on cognitive conversion of them.Methods:A total of 150 AD patients who admitted to Shanghai Mental Health Center from February 2022 to February 2024 were selected.The patients were divided into the observation group(75 cases)and the control group(75 cases)according to randomized numerical table.The control group received medicine treatment combined with conventional training,while the observation group received the treatment with biofeedback instrument on the basis of control group.The application effect and cognitive conversion of two groups were compared.Results:After treatment,the compliance rate and satisfaction rate of family’s members for treatment results in observation group were higher than those in control group,and the differences of them between two groups were significant(x^(2)=15.213,6.313,8.451,P<0.05).Compared with the various indicators of two groups before the biofeedback instrument was applied,they were improved after it was applied.Theβ-wave and sensorimotor rhythm(SMR)-wave of electroencephalogram,Mini-Mental State Examination(MMSE)scores,Montreal Cognitive Assessment(MoCA)scores of observation group were higher than those of control group,and theθ-wave and the scores of Activity of Daily Living Scale(ADL)were lower than those of control group,and the differences of them between two groups were significant(t=6.094,5.315,3.973,4.447,6.362,6.869,P<0.05),respectively.There was no significant difference in the rate of adverse reactions between the two groups(P>0.05).Conclusion:The application of biofeedback instrument in AD patients can promote cognitive conversion and improve self-care ability,which has higher safety.

关 键 词：阿尔兹海默病(AD) 生物反馈 认知功能 认知转归 

分 类 号：R749.16[医药卫生—神经病学与精神病学]